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Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity.
Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H, Chatterjee AK, Brinker A, Engels IH, Keiler KC. Ramadoss NS, et al. Among authors: chatterjee ak. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7. doi: 10.1073/pnas.1302816110. Epub 2013 Jun 3. Proc Natl Acad Sci U S A. 2013. PMID: 23733947 Free PMC article.
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, Trager R, Caldwell JS, Schultz PG, Zhou Y, Winzeler EA. Plouffe D, et al. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9059-64. doi: 10.1073/pnas.0802982105. Epub 2008 Jun 25. Proc Natl Acad Sci U S A. 2008. PMID: 18579783 Free PMC article.
Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.
Crowther GJ, Napuli AJ, Gilligan JH, Gagaring K, Borboa R, Francek C, Chen Z, Dagostino EF, Stockmyer JB, Wang Y, Rodenbough PP, Castaneda LJ, Leibly DJ, Bhandari J, Gelb MH, Brinker A, Engels IH, Taylor J, Chatterjee AK, Fantauzzi P, Glynne RJ, Van Voorhis WC, Kuhen KL. Crowther GJ, et al. Among authors: chatterjee ak. Mol Biochem Parasitol. 2011 Jan;175(1):21-9. doi: 10.1016/j.molbiopara.2010.08.005. Epub 2010 Sep 15. Mol Biochem Parasitol. 2011. PMID: 20813141 Free PMC article.
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.
Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, Mdluli KE, Franzblau S, Chatterjee AK, Johnsson K, Mikusova K, Besra GS, Fütterer K, Robbins SH, Barnes SW, Walker JR, Jacobs WR Jr, Schultz PG. Wang F, et al. Among authors: chatterjee ak. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7. doi: 10.1073/pnas.1309171110. Epub 2013 Jun 17. Proc Natl Acad Sci U S A. 2013. PMID: 23776209 Free PMC article.
Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors.
Zhang G, Baidin V, Pahil KS, Moison E, Tomasek D, Ramadoss NS, Chatterjee AK, McNamara CW, Young TS, Schultz PG, Meredith TC, Kahne D. Zhang G, et al. Among authors: chatterjee ak. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6834-6839. doi: 10.1073/pnas.1804670115. Epub 2018 May 7. Proc Natl Acad Sci U S A. 2018. PMID: 29735709 Free PMC article.
Small molecule selectively suppresses MYC transcription in cancer cells.
Bouvard C, Lim SM, Ludka J, Yazdani N, Woods AK, Chatterjee AK, Schultz PG, Zhu S. Bouvard C, et al. Among authors: chatterjee ak. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3497-3502. doi: 10.1073/pnas.1702663114. Epub 2017 Mar 14. Proc Natl Acad Sci U S A. 2017. PMID: 28292893 Free PMC article.
The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.
Janes J, Young ME, Chen E, Rogers NH, Burgstaller-Muehlbacher S, Hughes LD, Love MS, Hull MV, Kuhen KL, Woods AK, Joseph SB, Petrassi HM, McNamara CW, Tremblay MS, Su AI, Schultz PG, Chatterjee AK. Janes J, et al. Among authors: chatterjee ak. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10750-10755. doi: 10.1073/pnas.1810137115. Epub 2018 Oct 3. Proc Natl Acad Sci U S A. 2018. PMID: 30282735 Free PMC article.
Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant.
Wang RE, Wang Y, Zhang Y, Gabrelow C, Zhang Y, Chi V, Fu Q, Luo X, Wang D, Joseph S, Johnson K, Chatterjee AK, Wright TM, Nguyen-Tran VT, Teijaro J, Theofilopoulos AN, Schultz PG, Wang F. Wang RE, et al. Among authors: chatterjee ak. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11501-11506. doi: 10.1073/pnas.1612803113. Epub 2016 Sep 23. Proc Natl Acad Sci U S A. 2016. PMID: 27663736 Free PMC article.
329 results