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Inorganic mercury interacts with cysteine residues (C451 and C474) of hOCT2 to reduce its transport activity.
Pelis RM, Dangprapai Y, Wunz TM, Wright SH. Pelis RM, et al. Am J Physiol Renal Physiol. 2007 May;292(5):F1583-91. doi: 10.1152/ajprenal.00496.2006. Epub 2007 Feb 6. Am J Physiol Renal Physiol. 2007. PMID: 17287197 Free article.
Previously, of the cysteines (C437, C451, C470, and C474) that occur within transmembrane helices that comprise the hydrophilic cleft (proposed site of substrate binding), only C474 was accessible to maleimide-PEO(2)-biotin (hydrophilic thiol-reactive reagent), and covalent modif …
Previously, of the cysteines (C437, C451, C470, and C474) that occur within transmembrane helices that comprise the hydrophilic cleft (propo …
32 results