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Discovery of small-molecule modulators of the Sonic Hedgehog pathway.
Schaefer GI, Perez JR, Duvall JR, Stanton BZ, Shamji AF, Schreiber SL. Schaefer GI, et al. Among authors: stanton bz. J Am Chem Soc. 2013 Jul 3;135(26):9675-80. doi: 10.1021/ja400034k. Epub 2013 Jun 25. J Am Chem Soc. 2013. PMID: 23725514 Free PMC article.
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. Stanton BZ, et al. Nat Chem Biol. 2009 Mar;5(3):154-6. doi: 10.1038/nchembio.142. Epub 2009 Jan 18. Nat Chem Biol. 2009. PMID: 19151731 Free PMC article.
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.
Dockendorff C, Nagiec MM, Weïwer M, Buhrlage S, Ting A, Nag PP, Germain A, Kim HJ, Youngsaye W, Scherer C, Bennion M, Xue L, Stanton BZ, Lewis TA, Macpherson L, Palmer M, Foley MA, Perez JR, Schreiber SL. Dockendorff C, et al. Among authors: stanton bz. ACS Med Chem Lett. 2012 Oct 11;3(10):808-813. doi: 10.1021/ml300172p. Epub 2012 Aug 30. ACS Med Chem Lett. 2012. PMID: 23074541 Free PMC article.
Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7.
Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Lamb KN, et al. Among authors: stanton bz. Cell Chem Biol. 2019 Oct 17;26(10):1365-1379.e22. doi: 10.1016/j.chembiol.2019.07.013. Epub 2019 Aug 15. Cell Chem Biol. 2019. PMID: 31422906 Free PMC article.
38 results