Crabb SJ - Search Results

1

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase.

Tortorici M, Borrello MT, Tardugno M, Chiarelli LR, Pilotto S, Ciossani G, Vellore NA, Bailey SG, Cowan J, O'Connell M, Crabb SJ, Packham G, Mai A, Baron R, Ganesan A, Mattevi A. Tortorici M, et al. Among authors: crabb sj. ACS Chem Biol. 2013 Aug 16;8(8):1677-82. doi: 10.1021/cb4001926. Epub 2013 Jun 11. ACS Chem Biol. 2013. PMID: 23721412

2

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

Benelkebir H, Hodgkinson C, Duriez PJ, Hayden AL, Bulleid RA, Crabb SJ, Packham G, Ganesan A. Benelkebir H, et al. Among authors: crabb sj. Bioorg Med Chem. 2011 Jun 15;19(12):3709-16. doi: 10.1016/j.bmc.2011.02.017. Epub 2011 Feb 13. Bioorg Med Chem. 2011. PMID: 21382717

3

Synthesis of Carboxamide-Containing Tranylcypromine Analogues as LSD1 (KDM1A) Inhibitors Targeting Acute Myeloid Leukemia.

Teresa Borrello M, Benelkebir H, Lee A, Hin Tam C, Shafat M, Rushworth SA, Bowles KM, Douglas L, Duriez PJ, Bailey S, Crabb SJ, Packham G, Ganesan A. Teresa Borrello M, et al. Among authors: crabb sj. ChemMedChem. 2021 Apr 20;16(8):1316-1324. doi: 10.1002/cmdc.202000754. Epub 2021 Feb 3. ChemMedChem. 2021. PMID: 33533576

4

Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

Nolan L, Johnson PW, Ganesan A, Packham G, Crabb SJ. Nolan L, et al. Among authors: crabb sj. Br J Cancer. 2008 Sep 2;99(5):689-94. doi: 10.1038/sj.bjc.6604557. Epub 2008 Aug 19. Br J Cancer. 2008. PMID: 18728657 Free PMC article. Review.

5

LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.

Regufe da Mota S, Bailey S, Strivens RA, Hayden AL, Douglas LR, Duriez PJ, Borrello MT, Benelkebir H, Ganesan A, Packham G, Crabb SJ. Regufe da Mota S, et al. Among authors: crabb sj. Cancer Cell Int. 2018 May 9;18:71. doi: 10.1186/s12935-018-0568-1. eCollection 2018. Cancer Cell Int. 2018. PMID: 29760584 Free PMC article.

6

S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition.

Hayden A, Johnson PW, Packham G, Crabb SJ. Hayden A, et al. Among authors: crabb sj. Breast Cancer Res Treat. 2011 May;127(1):109-19. doi: 10.1007/s10549-010-0982-0. Epub 2010 Jun 17. Breast Cancer Res Treat. 2011. PMID: 20556507

7

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

Benelkebir H, Marie S, Hayden AL, Lyle J, Loadman PM, Crabb SJ, Packham G, Ganesan A. Benelkebir H, et al. Among authors: crabb sj. Bioorg Med Chem. 2011 Jun 15;19(12):3650-8. doi: 10.1016/j.bmc.2011.02.024. Epub 2011 Feb 17. Bioorg Med Chem. 2011. PMID: 21420302

8

Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.

Sharp A, Crabb SJ, Johnson PW, Hague A, Cutress R, Townsend PA, Ganesan A, Packham G. Sharp A, et al. Among authors: crabb sj. J Pharmacol Exp Ther. 2009 Nov;331(2):680-9. doi: 10.1124/jpet.109.153601. Epub 2009 Aug 18. J Pharmacol Exp Ther. 2009. PMID: 19690191 Free PMC article.

9

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer.

Whitton B, Okamoto H, Packham G, Crabb SJ. Whitton B, et al. Among authors: crabb sj. Cancer Med. 2018 Aug;7(8):3800-3811. doi: 10.1002/cam4.1594. Epub 2018 Jun 21. Cancer Med. 2018. PMID: 29926527 Free PMC article. Review.

10

Epigenetic therapy: histone acetylation, DNA methylation and anti-cancer drug discovery.

Ganesan A, Nolan L, Crabb SJ, Packham G. Ganesan A, et al. Among authors: crabb sj. Curr Cancer Drug Targets. 2009 Dec;9(8):963-81. doi: 10.2174/156800909790192428. Curr Cancer Drug Targets. 2009. PMID: 20025605 Review.

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