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Heavy chain-only IgG2b llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of coreceptor- and CD4-binding sites.
Acharya P, Luongo TS, Georgiev IS, Matz J, Schmidt SD, Louder MK, Kessler P, Yang Y, McKee K, O'Dell S, Chen L, Baty D, Chames P, Martin L, Mascola JR, Kwong PD. Acharya P, et al. Among authors: kessler p. J Virol. 2013 Sep;87(18):10173-81. doi: 10.1128/JVI.01332-13. Epub 2013 Jul 10. J Virol. 2013. PMID: 23843638 Free PMC article.
Elicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein.
Dey AK, Burke B, Sun Y, Sirokman K, Nandi A, Hartog K, Lian Y, Geonnotti AR, Montefiori D, Franti M, Martin G, Carfi A, Kessler P, Martin L, Srivastava IK, Barnett SW. Dey AK, et al. Among authors: kessler p. PLoS One. 2012;7(1):e30233. doi: 10.1371/journal.pone.0030233. Epub 2012 Jan 24. PLoS One. 2012. PMID: 22291921 Free PMC article.
Stabilization of HIV-1 envelope in the CD4-bound conformation through specific cross-linking of a CD4 mimetic.
Martin G, Burke B, Thaï R, Dey AK, Combes O, Ramos OH, Heyd B, Geonnotti AR, Montefiori DC, Kan E, Lian Y, Sun Y, Abache T, Ulmer JB, Madaoui H, Guérois R, Barnett SW, Srivastava IK, Kessler P, Martin L. Martin G, et al. Among authors: kessler p. J Biol Chem. 2011 Jun 17;286(24):21706-16. doi: 10.1074/jbc.M111.232272. Epub 2011 Apr 12. J Biol Chem. 2011. PMID: 21487012 Free PMC article.
MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques.
Dereuddre-Bosquet N, Morellato-Castillo L, Brouwers J, Augustijns P, Bouchemal K, Ponchel G, Ramos OH, Herrera C, Stefanidou M, Shattock R, Heyndrickx L, Vanham G, Kessler P, Le Grand R, Martin L. Dereuddre-Bosquet N, et al. Among authors: kessler p. PLoS Pathog. 2012;8(12):e1003071. doi: 10.1371/journal.ppat.1003071. Epub 2012 Dec 6. PLoS Pathog. 2012. PMID: 23236282 Free PMC article.
From a Cone Snail Toxin to a Competitive MC4R Antagonist.
Reynaud S, Laurin SA, Ciolek J, Barbe P, Van Baelen AC, Susset M, Blondel F, Ghazarian M, Boeri J, Vanden Driessche M, Upert G, Mourier G, Kessler P, Konnert L, Beroud R, Keck M, Servent D, Bouvier M, Gilles N. Reynaud S, et al. Among authors: kessler p. J Med Chem. 2022 Sep 22;65(18):12084-12094. doi: 10.1021/acs.jmedchem.2c00786. Epub 2022 Sep 5. J Med Chem. 2022. PMID: 36063022
526 results