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Short communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity.
Liu N, Denegri M, Ruan Y, Avelino-Cruz JE, Perissi A, Negri S, Napolitano C, Coetzee WA, Boyden PA, Priori SG. Liu N, et al. Among authors: denegri m. Circ Res. 2011 Jul 22;109(3):291-5. doi: 10.1161/CIRCRESAHA.111.247338. Epub 2011 Jun 16. Circ Res. 2011. PMID: 21680895
Single delivery of an adeno-associated viral construct to transfer the CASQ2 gene to knock-in mice affected by catecholaminergic polymorphic ventricular tachycardia is able to cure the disease from birth to advanced age.
Denegri M, Bongianino R, Lodola F, Boncompagni S, De Giusti VC, Avelino-Cruz JE, Liu N, Persampieri S, Curcio A, Esposito F, Pietrangelo L, Marty I, Villani L, Moyaho A, Baiardi P, Auricchio A, Protasi F, Napolitano C, Priori SG. Denegri M, et al. Circulation. 2014 Jun 24;129(25):2673-81. doi: 10.1161/CIRCULATIONAHA.113.006901. Epub 2014 Jun 2. Circulation. 2014. PMID: 24888331 Free article.
Allele-Specific Silencing of Mutant mRNA Rescues Ultrastructural and Arrhythmic Phenotype in Mice Carriers of the R4496C Mutation in the Ryanodine Receptor Gene (RYR2).
Bongianino R, Denegri M, Mazzanti A, Lodola F, Vollero A, Boncompagni S, Fasciano S, Rizzo G, Mangione D, Barbaro S, Di Fonso A, Napolitano C, Auricchio A, Protasi F, Priori SG. Bongianino R, et al. Among authors: denegri m. Circ Res. 2017 Aug 18;121(5):525-536. doi: 10.1161/CIRCRESAHA.117.310882. Epub 2017 Jun 15. Circ Res. 2017. PMID: 28620067
CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia.
Di Pasquale E, Lodola F, Miragoli M, Denegri M, Avelino-Cruz JE, Buonocore M, Nakahama H, Portararo P, Bloise R, Napolitano C, Condorelli G, Priori SG. Di Pasquale E, et al. Among authors: denegri m. Cell Death Dis. 2013 Oct 10;4(10):e843. doi: 10.1038/cddis.2013.369. Cell Death Dis. 2013. PMID: 24113177 Free PMC article.
Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.
Sedej S, Schmidt A, Denegri M, Walther S, Matovina M, Arnstein G, Gutschi EM, Windhager I, Ljubojević S, Negri S, Heinzel FR, Bisping E, Vos MA, Napolitano C, Priori SG, Kockskämper J, Pieske B. Sedej S, et al. Among authors: denegri m. J Am Coll Cardiol. 2014 Apr 22;63(15):1569-79. doi: 10.1016/j.jacc.2013.11.010. Epub 2013 Dec 4. J Am Coll Cardiol. 2014. PMID: 24315909 Free article.
Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia.
Lodola F, Morone D, Denegri M, Bongianino R, Nakahama H, Rutigliano L, Gosetti R, Rizzo G, Vollero A, Buonocore M, Napolitano C, Condorelli G, Priori SG, Di Pasquale E. Lodola F, et al. Among authors: denegri m. Cell Death Dis. 2016 Oct 6;7(10):e2393. doi: 10.1038/cddis.2016.304. Cell Death Dis. 2016. PMID: 27711080 Free PMC article.
78 results