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Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
Maynard A, Crosby RM, Ellis B, Hamatake R, Hong Z, Johns BA, Kahler KM, Koble C, Leivers A, Leivers MR, Mathis A, Peat AJ, Pouliot JJ, Roberts CD, Samano V, Schmidt RM, Smith GK, Spaltenstein A, Stewart EL, Thommes P, Turner EM, Voitenleitner C, Walker JT, Waitt G, Weatherhead J, Weaver K, Williams S, Wright L, Xiong ZZ, Haigh D, Shotwell JB. Maynard A, et al. Among authors: johns ba. J Med Chem. 2014 Mar 13;57(5):1902-13. doi: 10.1021/jm400317w. Epub 2013 May 29. J Med Chem. 2014. PMID: 23672667
Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents.
Johns BA, Gudmundsson KS, Turner EM, Allen SH, Samano VA, Ray JA, Freeman GA, Boyd FL Jr, Sexton CJ, Selleseth DW, Creech KL, Moniri KR. Johns BA, et al. Bioorg Med Chem. 2005 Apr 1;13(7):2397-411. doi: 10.1016/j.bmc.2005.01.044. Bioorg Med Chem. 2005. PMID: 15755642
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.
Garvey EP, Johns BA, Gartland MJ, Foster SA, Miller WH, Ferris RG, Hazen RJ, Underwood MR, Boros EE, Thompson JB, Weatherhead JG, Koble CS, Allen SH, Schaller LT, Sherrill RG, Yoshinaga T, Kobayashi M, Wakasa-Morimoto C, Miki S, Nakahara K, Noshi T, Sato A, Fujiwara T. Garvey EP, et al. Among authors: johns ba. Antimicrob Agents Chemother. 2008 Mar;52(3):901-8. doi: 10.1128/AAC.01218-07. Epub 2007 Dec 26. Antimicrob Agents Chemother. 2008. PMID: 18160521 Free PMC article.
62 results