Wexler RR - Search Results

1

New azole antagonists with high affinity for the P2Y(1) receptor.

Ruel R, L'Heureux A, Thibeault C, Daris JP, Martel A, Price LA, Wu Q, Hua J, Wexler RR, Rehfuss R, Lam PY. Ruel R, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3519-22. doi: 10.1016/j.bmcl.2013.04.041. Epub 2013 Apr 25. Bioorg Med Chem Lett. 2013. PMID: 23668989

2

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.

Carini DJ, Duncia JV, Aldrich PE, Chiu AT, Johnson AL, Pierce ME, Price WA, Santella JB 3rd, Wells GJ, Wexler RR, et al. Carini DJ, et al. Among authors: wexler rr. J Med Chem. 1991 Aug;34(8):2525-47. doi: 10.1021/jm00112a031. J Med Chem. 1991. PMID: 1875348

3

Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors.

Quan ML, Chiu AT, Ellis CD, Wong PC, Wexler RR, Timmermans PB. Quan ML, et al. Among authors: wexler rr. J Med Chem. 1995 Jul 21;38(15):2938-45. doi: 10.1021/jm00015a016. J Med Chem. 1995. PMID: 7636854

4

Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.

Wexler RR, Greenlee WJ, Irvin JD, Goldberg MR, Prendergast K, Smith RD, Timmermans PB. Wexler RR, et al. J Med Chem. 1996 Feb 2;39(3):625-56. doi: 10.1021/jm9504722. J Med Chem. 1996. PMID: 8576904 Review. No abstract available.

5

Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists.

Wityak J, Sielecki TM, Pinto DJ, Emmett G, Sze JY, Liu J, Tobin AE, Wang S, Jiang B, Ma P, Mousa SA, Wexler RR, Olson RE. Wityak J, et al. Among authors: wexler rr. J Med Chem. 1997 Jan 3;40(1):50-60. doi: 10.1021/jm960626t. J Med Chem. 1997. PMID: 9016328

6

The de novo design and synthesis of cyclic urea inhibitors of factor Xa: initial SAR studies.

Galemmo RA Jr, Maduskuie TP, Dominguez C, Rossi KA, Knabb RM, Wexler RR, Stouten PF. Galemmo RA Jr, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2705-10. doi: 10.1016/s0960-894x(98)00471-5. Bioorg Med Chem Lett. 1998. PMID: 9873607

7

Isoxazoline GPIIb/IIIa antagonists bearing a phosphoramidate.

Wityak J, Tobin AE, Mousa SA, Wexler RR, Olson RE. Wityak J, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 1999 Jan 18;9(2):123-6. doi: 10.1016/s0960-894x(98)00709-4. Bioorg Med Chem Lett. 1999. PMID: 10021912

8

Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

Pinto DJ, Orwat MJ, Wang S, Fevig JM, Quan ML, Amparo E, Cacciola J, Rossi KA, Alexander RS, Smallwood AM, Luettgen JM, Liang L, Aungst BJ, Wright MR, Knabb RM, Wong PC, Wexler RR, Lam PY. Pinto DJ, et al. Among authors: wexler rr. J Med Chem. 2001 Feb 15;44(4):566-78. doi: 10.1021/jm000409z. J Med Chem. 2001. PMID: 11170646

9

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.

Fevig JM, Pinto DJ, Han Q, Quan ML, Pruitt JR, Jacobson IC, Galemmo RA Jr, Wang S, Orwat MJ, Bostrom LL, Knabb RM, Wong PC, Lam PYS, Wexler RR. Fevig JM, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2001 Mar 12;11(5):641-5. doi: 10.1016/s0960-894x(01)00029-4. Bioorg Med Chem Lett. 2001. PMID: 11266160

10

Synthesis and pharmacology of modified amidine isoxazoline glycoprotein IIb/IIIa receptor antagonists.

Sielecki TM, Liu J, Mousa SA, Racanelli AL, Hausner EA, Wexler RR, Olson RE. Sielecki TM, et al. Among authors: wexler rr. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2201-4. doi: 10.1016/s0960-894x(01)00406-1. Bioorg Med Chem Lett. 2001. PMID: 11514170

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