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Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.
Ishii N, Harada N, Joseph EW, Ohara K, Miura T, Sakamoto H, Matsuda Y, Tomii Y, Tachibana-Kondo Y, Iikura H, Aoki T, Shimma N, Arisawa M, Sowa Y, Poulikakos PI, Rosen N, Aoki Y, Sakai T. Ishii N, et al. Among authors: sakamoto h. Cancer Res. 2013 Jul 1;73(13):4050-4060. doi: 10.1158/0008-5472.CAN-12-3937. Epub 2013 May 10. Cancer Res. 2013. PMID: 23667175 Free PMC article.
An orally available, small-molecule interferon inhibits viral replication.
Konishi H, Okamoto K, Ohmori Y, Yoshino H, Ohmori H, Ashihara M, Hirata Y, Ohta A, Sakamoto H, Hada N, Katsume A, Kohara M, Morikawa K, Tsukuda T, Shimma N, Foster GR, Alazawi W, Aoki Y, Arisawa M, Sudoh M. Konishi H, et al. Among authors: sakamoto h. Sci Rep. 2012;2:259. doi: 10.1038/srep00259. Epub 2012 Feb 10. Sci Rep. 2012. PMID: 22355771 Free PMC article.
Enantioselective synthesis of derivatives and structure-activity relationship study in the development of NA255 as a novel host-targeting anti-HCV agent.
Kawasaki K, Masubuchi M, Hayase T, Komiyama S, Watanabe F, Fukuda H, Murata T, Matsubara Y, Koyama K, Shindoh H, Sakamoto H, Okamato K, Ohta A, Katsume A, Aoki M, Aoki Y, Shimma N, Sudoh M, Tsukuda T. Kawasaki K, et al. Among authors: sakamoto h. Bioorg Med Chem Lett. 2013 Jan 1;23(1):336-9. doi: 10.1016/j.bmcl.2012.10.083. Epub 2012 Oct 30. Bioorg Med Chem Lett. 2013. PMID: 23164713
3,087 results