Joseph EW - Search Results

1

Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity.

Ishii N, Harada N, Joseph EW, Ohara K, Miura T, Sakamoto H, Matsuda Y, Tomii Y, Tachibana-Kondo Y, Iikura H, Aoki T, Shimma N, Arisawa M, Sowa Y, Poulikakos PI, Rosen N, Aoki Y, Sakai T. Ishii N, et al. Among authors: joseph ew. Cancer Res. 2013 Jul 1;73(13):4050-4060. doi: 10.1158/0008-5472.CAN-12-3937. Epub 2013 May 10. Cancer Res. 2013. PMID: 23667175 Free PMC article.

2

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.

Lito P, Saborowski A, Yue J, Solomon M, Joseph E, Gadal S, Saborowski M, Kastenhuber E, Fellmann C, Ohara K, Morikami K, Miura T, Lukacs C, Ishii N, Lowe S, Rosen N. Lito P, et al. Cancer Cell. 2014 May 12;25(5):697-710. doi: 10.1016/j.ccr.2014.03.011. Epub 2014 Apr 17. Cancer Cell. 2014. PMID: 24746704 Free PMC article.

3

Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas.

Lito P, Pratilas CA, Joseph EW, Tadi M, Halilovic E, Zubrowski M, Huang A, Wong WL, Callahan MK, Merghoub T, Wolchok JD, de Stanchina E, Chandarlapaty S, Poulikakos PI, Fagin JA, Rosen N. Lito P, et al. Among authors: joseph ew. Cancer Cell. 2012 Nov 13;22(5):668-82. doi: 10.1016/j.ccr.2012.10.009. Cancer Cell. 2012. PMID: 23153539 Free PMC article.

4

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner.

Joseph EW, Pratilas CA, Poulikakos PI, Tadi M, Wang W, Taylor BS, Halilovic E, Persaud Y, Xing F, Viale A, Tsai J, Chapman PB, Bollag G, Solit DB, Rosen N. Joseph EW, et al. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14903-8. doi: 10.1073/pnas.1008990107. Epub 2010 Jul 28. Proc Natl Acad Sci U S A. 2010. PMID: 20668238 Free PMC article.

5

Cyclic AMP as a modulator of polarity in polycistronic transcriptional units.

Ullmann A, Joseph E, Danchin A. Ullmann A, et al. Proc Natl Acad Sci U S A. 1979 Jul;76(7):3194-7. doi: 10.1073/pnas.76.7.3194. Proc Natl Acad Sci U S A. 1979. PMID: 226959 Free PMC article.

6

Regulation of galactose operon expression: glucose effects and role of cyclic adenosine 3',5'-monophosphate.

Joseph E, Danchin A, Ullmann A. Joseph E, et al. J Bacteriol. 1981 Apr;146(1):149-54. doi: 10.1128/jb.146.1.149-154.1981. J Bacteriol. 1981. PMID: 6260740 Free PMC article.

7

Transcription-translation coupling and polarity: a possible role of cyclic AMP.

Danchin A, Dondon L, Joseph E, Ullmann A. Danchin A, et al. Biochimie. 1981;63(5):419-24. doi: 10.1016/s0300-9084(81)80015-6. Biochimie. 1981. PMID: 6263357

8

Formylation of initiator tRNA methionine in procaryotic protein synthesis: in vivo polarity in lactose operon expression.

Petersen HU, Joseph E, Ullmann A, Danchin A. Petersen HU, et al. J Bacteriol. 1978 Aug;135(2):453-9. doi: 10.1128/jb.135.2.453-459.1978. J Bacteriol. 1978. PMID: 98518 Free PMC article.

9

Multiple regulation of the activity of adenylate cyclase in Escherichia coli.

Joseph E, Bernsley C, Guiso N, Ullmann A. Joseph E, et al. Mol Gen Genet. 1982;185(2):262-8. doi: 10.1007/BF00330796. Mol Gen Genet. 1982. PMID: 6283317

10

Modulation of the lactose operon mRNA turnover by inhibitors of dihydrofolate reductase.

Joseph E, Danchin A, Ullmann A. Joseph E, et al. Biochem Biophys Res Commun. 1978 Oct 16;84(3):769-76. doi: 10.1016/0006-291x(78)90771-4. Biochem Biophys Res Commun. 1978. PMID: 102326 No abstract available.

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