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Challenges in the development of heteromer-GPCR-based drugs.
Franco R, Martínez-Pinilla E, Ricobaraza A, McCormick PJ. Franco R, et al. Among authors: mccormick pj. Prog Mol Biol Transl Sci. 2013;117:143-62. doi: 10.1016/B978-0-12-386931-9.00006-4. Prog Mol Biol Transl Sci. 2013. PMID: 23663968 Review.
L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.
Pinna A, Bonaventura J, Farré D, Sánchez M, Simola N, Mallol J, Lluís C, Costa G, Baqi Y, Müller CE, Cortés A, McCormick P, Canela EI, Martínez-Pinilla E, Lanciego JL, Casadó V, Armentero MT, Franco R. Pinna A, et al. Exp Neurol. 2014 Mar;253:180-91. doi: 10.1016/j.expneurol.2013.12.021. Epub 2014 Jan 9. Exp Neurol. 2014. PMID: 24412491
L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus.
Bonaventura J, Rico AJ, Moreno E, Sierra S, Sánchez M, Luquin N, Farré D, Müller CE, Martínez-Pinilla E, Cortés A, Mallol J, Armentero MT, Pinna A, Canela EI, Lluís C, McCormick PJ, Lanciego JL, Casadó V, Franco R. Bonaventura J, et al. Among authors: mccormick pj. Neuropharmacology. 2014 Apr;79:90-100. doi: 10.1016/j.neuropharm.2013.10.036. Epub 2013 Nov 11. Neuropharmacology. 2014. PMID: 24230991
Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.
Navarro G, Cordomí A, Zelman-Femiak M, Brugarolas M, Moreno E, Aguinaga D, Perez-Benito L, Cortés A, Casadó V, Mallol J, Canela EI, Lluís C, Pardo L, García-Sáez AJ, McCormick PJ, Franco R. Navarro G, et al. Among authors: mccormick pj. BMC Biol. 2016 Apr 5;14:26. doi: 10.1186/s12915-016-0247-4. BMC Biol. 2016. PMID: 27048449 Free PMC article.
Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease.
Rodríguez-Ruiz M, Moreno E, Moreno-Delgado D, Navarro G, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, McCormick PJ, Franco R. Rodríguez-Ruiz M, et al. Among authors: mccormick pj. Mol Neurobiol. 2017 Aug;54(6):4537-4550. doi: 10.1007/s12035-016-9995-y. Epub 2016 Jul 1. Mol Neurobiol. 2017. PMID: 27370794
Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain.
González S, Rangel-Barajas C, Peper M, Lorenzo R, Moreno E, Ciruela F, Borycz J, Ortiz J, Lluís C, Franco R, McCormick PJ, Volkow ND, Rubinstein M, Floran B, Ferré S. González S, et al. Among authors: mccormick pj. Mol Psychiatry. 2012 Jun;17(6):650-62. doi: 10.1038/mp.2011.93. Epub 2011 Aug 16. Mol Psychiatry. 2012. PMID: 21844870 Free PMC article.
Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers.
Navarro G, Moreno E, Bonaventura J, Brugarolas M, Farré D, Aguinaga D, Mallol J, Cortés A, Casadó V, Lluís C, Ferre S, Franco R, Canela E, McCormick PJ. Navarro G, et al. Among authors: mccormick pj. PLoS One. 2013 Apr 18;8(4):e61245. doi: 10.1371/journal.pone.0061245. Print 2013. PLoS One. 2013. PMID: 23637801 Free PMC article.
182 results