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New active drugs against liver stages of Plasmodium predicted by molecular topology.
Mahmoudi N, Garcia-Domenech R, Galvez J, Farhati K, Franetich JF, Sauerwein R, Hannoun L, Derouin F, Danis M, Mazier D. Mahmoudi N, et al. Among authors: sauerwein r. Antimicrob Agents Chemother. 2008 Apr;52(4):1215-20. doi: 10.1128/AAC.01043-07. Epub 2008 Jan 22. Antimicrob Agents Chemother. 2008. PMID: 18212104 Free PMC article.
The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector.
van Pelt-Koops JC, Pett HE, Graumans W, van der Vegte-Bolmer M, van Gemert GJ, Rottmann M, Yeung BK, Diagana TT, Sauerwein RW. van Pelt-Koops JC, et al. Among authors: sauerwein rw. Antimicrob Agents Chemother. 2012 Jul;56(7):3544-8. doi: 10.1128/AAC.06377-11. Epub 2012 Apr 16. Antimicrob Agents Chemother. 2012. PMID: 22508309 Free PMC article.
A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages.
Tibúrcio M, Niang M, Deplaine G, Perrot S, Bischoff E, Ndour PA, Silvestrini F, Khattab A, Milon G, David PH, Hardeman M, Vernick KD, Sauerwein RW, Preiser PR, Mercereau-Puijalon O, Buffet P, Alano P, Lavazec C. Tibúrcio M, et al. Among authors: sauerwein rw. Blood. 2012 Jun 14;119(24):e172-80. doi: 10.1182/blood-2012-03-414557. Epub 2012 Apr 18. Blood. 2012. PMID: 22517905 Free PMC article.
Targeting Plasmodium PI(4)K to eliminate malaria.
McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TS, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Nagle A, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA. McNamara CW, et al. Among authors: sauerwein rw. Nature. 2013 Dec 12;504(7479):248-253. doi: 10.1038/nature12782. Epub 2013 Nov 27. Nature. 2013. PMID: 24284631 Free PMC article.
456 results