Takeda S - Search Results

1

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease.

Takeda S, Hashimoto T, Roe AD, Hori Y, Spires-Jones TL, Hyman BT. Takeda S, et al. FASEB J. 2013 Aug;27(8):3239-48. doi: 10.1096/fj.13-229666. Epub 2013 May 2. FASEB J. 2013. PMID: 23640054 Free PMC article.

2

Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.

Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Hashimoto T, et al. Among authors: takeda s. J Neurosci. 2012 Oct 24;32(43):15181-92. doi: 10.1523/JNEUROSCI.1542-12.2012. J Neurosci. 2012. PMID: 23100439 Free PMC article.

3

Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain.

Hudry E, Dashkoff J, Roe AD, Takeda S, Koffie RM, Hashimoto T, Scheel M, Spires-Jones T, Arbel-Ornath M, Betensky R, Davidson BL, Hyman BT. Hudry E, et al. Among authors: takeda s. Sci Transl Med. 2013 Nov 20;5(212):212ra161. doi: 10.1126/scitranslmed.3007000. Sci Transl Med. 2013. PMID: 24259049 Free PMC article.

4

A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.

Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E. Hori Y, et al. Among authors: takeda s. J Biol Chem. 2015 Jan 23;290(4):1966-78. doi: 10.1074/jbc.M114.586602. Epub 2014 Dec 2. J Biol Chem. 2015. PMID: 25468905 Free PMC article.

5

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.

Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. Takeda S, et al. Nat Commun. 2015 Oct 13;6:8490. doi: 10.1038/ncomms9490. Nat Commun. 2015. PMID: 26458742 Free PMC article.

6

Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.

Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT. Takeda S, et al. Ann Neurol. 2016 Sep;80(3):355-67. doi: 10.1002/ana.24716. Epub 2016 Aug 3. Ann Neurol. 2016. PMID: 27351289 Free PMC article.

7

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.

Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ. Arbel-Ornath M, et al. Among authors: takeda s. Mol Neurodegener. 2017 Mar 21;12(1):27. doi: 10.1186/s13024-017-0169-9. Mol Neurodegener. 2017. PMID: 28327181 Free PMC article.

8

Oxidative stress and lipid peroxidation are upstream of amyloid pathology.

Arimon M, Takeda S, Post KL, Svirsky S, Hyman BT, Berezovska O. Arimon M, et al. Among authors: takeda s. Neurobiol Dis. 2015 Dec;84:109-19. doi: 10.1016/j.nbd.2015.06.013. Epub 2015 Jun 21. Neurobiol Dis. 2015. PMID: 26102023 Free PMC article.

9

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.

Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, Hyman BT. Wegmann S, et al. Among authors: takeda s. EMBO J. 2015 Dec 14;34(24):3028-41. doi: 10.15252/embj.201592748. Epub 2015 Nov 4. EMBO J. 2015. PMID: 26538322 Free PMC article.

10

Formation, release, and internalization of stable tau oligomers in cells.

Wegmann S, Nicholls S, Takeda S, Fan Z, Hyman BT. Wegmann S, et al. Among authors: takeda s. J Neurochem. 2016 Dec;139(6):1163-1174. doi: 10.1111/jnc.13866. Epub 2016 Nov 10. J Neurochem. 2016. PMID: 27731899 Free PMC article.

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