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Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, Raskind MA, Li G, Montine TJ, Frosch MP, Hyman BT. Takeda S, et al. Among authors: roe ad. Ann Neurol. 2016 Sep;80(3):355-67. doi: 10.1002/ana.24716. Epub 2016 Aug 3. Ann Neurol. 2016. PMID: 27351289 Free PMC article.
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.
Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, Hyman BT. Wegmann S, et al. EMBO J. 2015 Dec 14;34(24):3028-41. doi: 10.15252/embj.201592748. Epub 2015 Nov 4. EMBO J. 2015. PMID: 26538322 Free PMC article.
Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.
Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, Dunah AW, Wittmann M, Bussiere T, Weinreb PH, Hyman BT, Takeda S. Nobuhara CK, et al. Among authors: roe ad. Am J Pathol. 2017 Jun;187(6):1399-1412. doi: 10.1016/j.ajpath.2017.01.022. Epub 2017 Apr 11. Am J Pathol. 2017. PMID: 28408124 Free PMC article.
Enhanced Tau Aggregation in the Presence of Amyloid β.
Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson GA, Hyman BT. Bennett RE, et al. Among authors: roe ad. Am J Pathol. 2017 Jul;187(7):1601-1612. doi: 10.1016/j.ajpath.2017.03.011. Epub 2017 May 10. Am J Pathol. 2017. PMID: 28500862 Free PMC article.
57 results