Smith TK - Search Results

1

Total synthesis, stereochemical assignment, and biological activity of chamuvarinin and structural analogues.

Florence GJ, Morris JC, Murray RG, Vanga RR, Osler JD, Smith TK. Florence GJ, et al. Among authors: smith tk. Chemistry. 2013 Jun 17;19(25):8309-20. doi: 10.1002/chem.201204527. Epub 2013 Apr 29. Chemistry. 2013. PMID: 23630031

2

Synthesis and stereochemical assignment of (+)-chamuvarinin.

Florence GJ, Morris JC, Murray RG, Osler JD, Reddy VR, Smith TK. Florence GJ, et al. Among authors: smith tk. Org Lett. 2011 Feb 4;13(3):514-7. doi: 10.1021/ol1028699. Epub 2010 Dec 21. Org Lett. 2011. PMID: 21174397 Free PMC article.

3

A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.

Zhou L, Stewart G, Rideau E, Westwood NJ, Smith TK. Zhou L, et al. Among authors: smith tk. J Med Chem. 2013 Feb 14;56(3):796-806. doi: 10.1021/jm301215e. Epub 2013 Jan 15. J Med Chem. 2013. PMID: 23281892 Free PMC article.

4

Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors.

Florence GJ, Fraser AL, Gould ER, King EF, Menzies SK, Morris JC, Tulloch LB, Smith TK. Florence GJ, et al. Among authors: smith tk. ChemMedChem. 2014 Nov;9(11):2548-56. doi: 10.1002/cmdc.201402272. Epub 2014 Aug 21. ChemMedChem. 2014. PMID: 25145275 Free PMC article.

5

Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors.

Florence GJ, Fraser AL, Gould ER, King EF, Menzies SK, Morris JC, Thomson MI, Tulloch LB, Zacharova MK, Smith TK. Florence GJ, et al. Among authors: smith tk. ChemMedChem. 2016 Jul 19;11(14):1503-6. doi: 10.1002/cmdc.201600210. Epub 2016 Jun 10. ChemMedChem. 2016. PMID: 27283448 Free PMC article.

6

The trypanosome alternative oxidase: a potential drug target?

Menzies SK, Tulloch LB, Florence GJ, Smith TK. Menzies SK, et al. Among authors: smith tk. Parasitology. 2018 Feb;145(2):175-183. doi: 10.1017/S0031182016002109. Epub 2016 Nov 29. Parasitology. 2018. PMID: 27894362 Review.

7

Simplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins.

Gould ER, King EFB, Menzies SK, Fraser AL, Tulloch LB, Zacharova MK, Smith TK, Florence GJ. Gould ER, et al. Among authors: smith tk. Bioorg Med Chem. 2017 Nov 15;25(22):6126-6136. doi: 10.1016/j.bmc.2017.01.021. Epub 2017 Jan 28. Bioorg Med Chem. 2017. PMID: 28185724

8

Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues.

Tulloch LB, Menzies SK, Fraser AL, Gould ER, King EF, Zacharova MK, Florence GJ, Smith TK. Tulloch LB, et al. Among authors: smith tk. PLoS Negl Trop Dis. 2017 Sep 5;11(9):e0005886. doi: 10.1371/journal.pntd.0005886. eCollection 2017 Sep. PLoS Negl Trop Dis. 2017. PMID: 28873407 Free PMC article.

9

Direct and indirect approaches to identify drug modes of action.

Tulloch LB, Menzies SK, Coron RP, Roberts MD, Florence GJ, Smith TK. Tulloch LB, et al. Among authors: smith tk. IUBMB Life. 2018 Jan;70(1):9-22. doi: 10.1002/iub.1697. Epub 2017 Dec 6. IUBMB Life. 2018. PMID: 29210173 Free article. Review.

10

Design and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors.

Fraser AL, Menzies SK, King EFB, Tulloch LB, Gould ER, Zacharova MK, Smith TK, Florence GJ. Fraser AL, et al. Among authors: smith tk. ACS Infect Dis. 2018 Apr 13;4(4):560-567. doi: 10.1021/acsinfecdis.7b00187. Epub 2018 Jan 19. ACS Infect Dis. 2018. PMID: 29313667

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