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Distance between the basic group of the amino acid residue's side chain in position P1 of trypsin inhibitor CMTI-III and Asp189 in the substrate pocket of trypsin has an essential influence on the inhibitory activity.
Jaśkiewicz A, Lesner A, Rózycki J, Rodziewicz S, Rolka K, Ragnarsson U, Kupryszewski G. Jaśkiewicz A, et al. Among authors: rolka k. Biochem Biophys Res Commun. 1997 Nov 26;240(3):869-71. doi: 10.1006/bbrc.1997.7752. Biochem Biophys Res Commun. 1997. PMID: 9398660
Substrate specificity of human matriptase-2.
Wysocka M, Gruba N, Miecznikowska A, Popow-Stellmaszyk J, Gütschow M, Stirnberg M, Furtmann N, Bajorath J, Lesner A, Rolka K. Wysocka M, et al. Among authors: rolka k. Biochimie. 2014 Feb;97:121-7. doi: 10.1016/j.biochi.2013.10.001. Epub 2013 Oct 22. Biochimie. 2014. PMID: 24161741
120 results