Foster D - Search Results

1

Lipid nanoparticles improve activity of single-stranded siRNA and gapmer antisense oligonucleotides in animals.

Prakash TP, Lima WF, Murray HM, Elbashir S, Cantley W, Foster D, Jayaraman M, Chappell AE, Manoharan M, Swayze EE, Crooke ST. Prakash TP, et al. Among authors: foster d. ACS Chem Biol. 2013 Jul 19;8(7):1402-6. doi: 10.1021/cb4001316. Epub 2013 May 2. ACS Chem Biol. 2013. PMID: 23614580

2

Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo.

Foster DJ, Barros S, Duncan R, Shaikh S, Cantley W, Dell A, Bulgakova E, O'Shea J, Taneja N, Kuchimanchi S, Sherrill CB, Akinc A, Hinkle G, Seila White AC, Pang B, Charisse K, Meyers R, Manoharan M, Elbashir SM. Foster DJ, et al. RNA. 2012 Mar;18(3):557-68. doi: 10.1261/rna.031120.111. Epub 2012 Jan 31. RNA. 2012. PMID: 22294662 Free PMC article.

3

5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.

Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M. Zlatev I, et al. ACS Chem Biol. 2016 Apr 15;11(4):953-60. doi: 10.1021/acschembio.5b00654. Epub 2016 Jan 13. ACS Chem Biol. 2016. PMID: 26675211

4

Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.

Schlegel MK, Foster DJ, Kel'in AV, Zlatev I, Bisbe A, Jayaraman M, Lackey JG, Rajeev KG, Charissé K, Harp J, Pallan PS, Maier MA, Egli M, Manoharan M. Schlegel MK, et al. J Am Chem Soc. 2017 Jun 28;139(25):8537-8546. doi: 10.1021/jacs.7b02694. Epub 2017 Jun 19. J Am Chem Soc. 2017. PMID: 28570818

5

5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V. Parmar R, et al. Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130. Epub 2016 Apr 28. Chembiochem. 2016. PMID: 27121751

6

Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.

Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG. Parmar RG, et al. J Med Chem. 2018 Feb 8;61(3):734-744. doi: 10.1021/acs.jmedchem.7b01147. Epub 2018 Jan 27. J Med Chem. 2018. PMID: 29376650

7

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates.

Foster DJ, Brown CR, Shaikh S, Trapp C, Schlegel MK, Qian K, Sehgal A, Rajeev KG, Jadhav V, Manoharan M, Kuchimanchi S, Maier MA, Milstein S. Foster DJ, et al. Mol Ther. 2018 Mar 7;26(3):708-717. doi: 10.1016/j.ymthe.2017.12.021. Epub 2018 Jan 4. Mol Ther. 2018. PMID: 29456020 Free PMC article.

8

Activation of LDL receptor expression by small RNAs complementary to a noncoding transcript that overlaps the LDLR promoter.

Matsui M, Sakurai F, Elbashir S, Foster DJ, Manoharan M, Corey DR. Matsui M, et al. Chem Biol. 2010 Dec 22;17(12):1344-55. doi: 10.1016/j.chembiol.2010.10.009. Chem Biol. 2010. PMID: 21168770 Free PMC article.

9

5'-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger.

Kumar P , Parmar RG , Brown CR , Willoughby JLS , Foster DJ , Babu IR , Schofield S , Jadhav V , Charisse K , Nair JK , Rajeev KG , Maier MA , Egli M , Manoharan M . Kumar P , et al. Chem Commun (Camb). 2019 Apr 25;55(35):5139-5142. doi: 10.1039/c9cc00977a. Chem Commun (Camb). 2019. PMID: 30977478

10

4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.

Malek-Adamian E, Guenther DC, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury J, Perkins L, Moitessier N, Manoharan RM, Taneja N, Bisbe A, Charisse K, Maier M, Rajeev KG, Egli M, Manoharan M, Damha MJ. Malek-Adamian E, et al. J Am Chem Soc. 2017 Oct 18;139(41):14542-14555. doi: 10.1021/jacs.7b07582. Epub 2017 Oct 6. J Am Chem Soc. 2017. PMID: 28937776

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