Xi G - Search Results

1

Recruitment of Nox4 to a plasma membrane scaffold is required for localized reactive oxygen species generation and sustained Src activation in response to insulin-like growth factor-I.

Xi G, Shen XC, Wai C, Clemmons DR. Xi G, et al. J Biol Chem. 2013 May 31;288(22):15641-53. doi: 10.1074/jbc.M113.456046. Epub 2013 Apr 23. J Biol Chem. 2013. PMID: 23612968 Free PMC article.

2

Hyperglycemia alters the responsiveness of smooth muscle cells to insulin-like growth factor-I.

Maile LA, Capps BE, Ling Y, Xi G, Clemmons DR. Maile LA, et al. Among authors: xi g. Endocrinology. 2007 May;148(5):2435-43. doi: 10.1210/en.2006-1440. Epub 2007 Jan 25. Endocrinology. 2007. PMID: 17255202

3

Expression of the human beta3 integrin subunit in mouse smooth muscle cells enhances IGF-I-stimulated signaling and proliferation.

Xi G, Maile LA, Yoo SE, Clemmons DR. Xi G, et al. J Cell Physiol. 2008 Feb;214(2):306-15. doi: 10.1002/jcp.21196. J Cell Physiol. 2008. PMID: 17607710

4

p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 membrane recruitment.

Xi G, Shen X, Clemmons DR. Xi G, et al. Mol Endocrinol. 2008 Sep;22(9):2162-75. doi: 10.1210/me.2008-0079. Epub 2008 Jul 7. Mol Endocrinol. 2008. PMID: 18606861 Free PMC article.

5

Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells.

Shen X, Xi G, Radhakrishnan Y, Clemmons DR. Shen X, et al. Among authors: xi g. Mol Cell Proteomics. 2009 Jul;8(7):1539-51. doi: 10.1074/mcp.M800543-MCP200. Epub 2009 Mar 18. Mol Cell Proteomics. 2009. PMID: 19299420 Free PMC article.

6

p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation.

Xi G, Shen X, Clemmons DR. Xi G, et al. J Biol Chem. 2010 Mar 5;285(10):6937-51. doi: 10.1074/jbc.M109.069872. Epub 2010 Jan 4. J Biol Chem. 2010. PMID: 20048152 Free PMC article.

7

Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells.

Shen X, Xi G, Radhakrishnan Y, Clemmons DR. Shen X, et al. Among authors: xi g. Cell Mol Life Sci. 2010 Nov;67(22):3893-903. doi: 10.1007/s00018-010-0411-x. Epub 2010 Jun 3. Cell Mol Life Sci. 2010. PMID: 20521079 Free PMC article.

8

Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells.

Xi G, Shen X, Radhakrishnan Y, Maile L, Clemmons D. Xi G, et al. Endocrinology. 2010 Aug;151(8):3611-23. doi: 10.1210/en.2010-0242. Epub 2010 Jun 9. Endocrinology. 2010. PMID: 20534722 Free PMC article.

9

PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival.

Shen X, Xi G, Radhakrishnan Y, Clemmons DR. Shen X, et al. Among authors: xi g. J Biol Chem. 2010 Sep 17;285(38):29416-24. doi: 10.1074/jbc.M110.155325. Epub 2010 Jul 19. J Biol Chem. 2010. PMID: 20643654 Free PMC article.

10

Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells.

Ning J, Xi G, Clemmons DR. Ning J, et al. Among authors: xi g. Endocrinology. 2011 Aug;152(8):3143-54. doi: 10.1210/en.2011-0155. Epub 2011 Jun 14. Endocrinology. 2011. PMID: 21673100 Free PMC article.

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