Fairbrother WJ - Search Results

1

Structure-guided design of a selective BCL-X(L) inhibitor.

Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KN, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJ, Kulasegaram S, Moss RM, Parisot JP, Smith BJ, Street IP, Yang H, Huang DC, Watson KG. Lessene G, et al. Among authors: fairbrother wj. Nat Chem Biol. 2013 Jun;9(6):390-7. doi: 10.1038/nchembio.1246. Epub 2013 Apr 21. Nat Chem Biol. 2013. PMID: 23603658

2

SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).

Vucic D, Deshayes K, Ackerly H, Pisabarro MT, Kadkhodayan S, Fairbrother WJ, Dixit VM. Vucic D, et al. Among authors: fairbrother wj. J Biol Chem. 2002 Apr 5;277(14):12275-9. doi: 10.1074/jbc.M112045200. Epub 2002 Jan 18. J Biol Chem. 2002. PMID: 11801603 Free article.

3

Exploring protein-protein interactions with phage display.

Sidhu SS, Fairbrother WJ, Deshayes K. Sidhu SS, et al. Among authors: fairbrother wj. Chembiochem. 2003 Jan 3;4(1):14-25. doi: 10.1002/cbic.200390008. Chembiochem. 2003. PMID: 12512072 Review.

4

Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).

Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Mausisa G, Okawa DC, Ong D, Vucic D, Deshayes K, Fairbrother WJ. Franklin MC, et al. Among authors: fairbrother wj. Biochemistry. 2003 Jul 15;42(27):8223-31. doi: 10.1021/bi034227t. Biochemistry. 2003. PMID: 12846571

5

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Zobel K, et al. Among authors: fairbrother wj. ACS Chem Biol. 2006 Sep 19;1(8):525-33. doi: 10.1021/cb600276q. ACS Chem Biol. 2006. PMID: 17168540

6

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, Flygare JA, Fairbrother WJ, Deshayes K, Dixit VM, Vucic D. Varfolomeev E, et al. Among authors: fairbrother wj. Cell. 2007 Nov 16;131(4):669-81. doi: 10.1016/j.cell.2007.10.030. Cell. 2007. PMID: 18022362 Free article.

7

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.

Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, Vucic D. Varfolomeev E, et al. Among authors: fairbrother wj. J Biol Chem. 2008 Sep 5;283(36):24295-9. doi: 10.1074/jbc.C800128200. Epub 2008 Jul 11. J Biol Chem. 2008. PMID: 18621737 Free PMC article.

8

Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold.

Cohen F, Alicke B, Elliott LO, Flygare JA, Goncharov T, Keteltas SF, Franklin MC, Frankovitz S, Stephan JP, Tsui V, Vucic D, Wong H, Fairbrother WJ. Cohen F, et al. Among authors: fairbrother wj. J Med Chem. 2009 Mar 26;52(6):1723-30. doi: 10.1021/jm801450c. J Med Chem. 2009. PMID: 19228017

9

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

Ndubaku C, Varfolomeev E, Wang L, Zobel K, Lau K, Elliott LO, Maurer B, Fedorova AV, Dynek JN, Koehler M, Hymowitz SG, Tsui V, Deshayes K, Fairbrother WJ, Flygare JA, Vucic D. Ndubaku C, et al. Among authors: fairbrother wj. ACS Chem Biol. 2009 Jul 17;4(7):557-66. doi: 10.1021/cb900083m. ACS Chem Biol. 2009. PMID: 19492850

10

Small-molecule pan-IAP antagonists: a patent review.

Flygare JA, Fairbrother WJ. Flygare JA, et al. Among authors: fairbrother wj. Expert Opin Ther Pat. 2010 Feb;20(2):251-67. doi: 10.1517/13543770903567077. Expert Opin Ther Pat. 2010. PMID: 20100005 Review.

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