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Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat.
Jones AR, Woollacott I, Shatunov A, Cooper-Knock J, Buchman V, Sproviero W, Smith B, Scott KM, Balendra R, Abel O, McGuffin P, Ellis CM, Shaw PJ, Morrison KE, Farmer A, Lewis CM, Leigh PN, Shaw CE, Powell JF, Al-Chalabi A. Jones AR, et al. Among authors: balendra r. Neurobiol Aging. 2013 Sep;34(9):2234.e1-7. doi: 10.1016/j.neurobiolaging.2013.03.003. Epub 2013 Apr 12. Neurobiol Aging. 2013. PMID: 23587638 Free PMC article.
Use of clinical staging in amyotrophic lateral sclerosis for phase 3 clinical trials.
Balendra R, Jones A, Jivraj N, Steen IN, Young CA, Shaw PJ, Turner MR, Leigh PN, Al-Chalabi A; UK-MND LiCALS Study Group, Mito Target ALS Study Group. Balendra R, et al. J Neurol Neurosurg Psychiatry. 2015 Jan;86(1):45-9. doi: 10.1136/jnnp-2013-306865. Epub 2014 Jan 24. J Neurol Neurosurg Psychiatry. 2015. PMID: 24463480 Free article.
Health utility decreases with increasing clinical stage in amyotrophic lateral sclerosis.
Jones AR, Jivraj N, Balendra R, Murphy C, Kelly J, Thornhill M, Young C, Shaw PJ, Leigh PN, Turner MR, Steen IN, McCrone P, Al-Chalabi A. Jones AR, et al. Among authors: balendra r. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jun;15(3-4):285-91. doi: 10.3109/21678421.2013.872149. Epub 2014 Feb 7. Amyotroph Lateral Scler Frontotemporal Degener. 2014. PMID: 24641613
Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration.
Mizielinska S, Ridler CE, Balendra R, Thoeng A, Woodling NS, Grässer FA, Plagnol V, Lashley T, Partridge L, Isaacs AM. Mizielinska S, et al. Among authors: balendra r. Acta Neuropathol Commun. 2017 Apr 18;5(1):29. doi: 10.1186/s40478-017-0432-x. Acta Neuropathol Commun. 2017. PMID: 28420437 Free PMC article.
G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.
Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, Calvo A, Chio A, Houlden H, Polke JM, Ismail MA, Stephens CE, Vo T, Farahat AA, Wilson WD, Boykin DW, Zetterberg H, Partridge L, Wray S, Parkinson G, Neidle S, Patani R, Fratta P, Isaacs AM. Simone R, et al. Among authors: balendra r. EMBO Mol Med. 2018 Jan;10(1):22-31. doi: 10.15252/emmm.201707850. EMBO Mol Med. 2018. PMID: 29113975 Free PMC article.
A standard operating procedure for King's ALS clinical staging.
Balendra R, Al Khleifat A, Fang T, Al-Chalabi A. Balendra R, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May;20(3-4):159-164. doi: 10.1080/21678421.2018.1556696. Epub 2019 Feb 18. Amyotroph Lateral Scler Frontotemporal Degener. 2019. PMID: 30773950 Free PMC article.
Intuitive Staging Correlates With King's Clinical Stage.
Al Khleifat A, Balendra R, Fang T, Al-Chalabi A. Al Khleifat A, et al. Among authors: balendra r. Amyotroph Lateral Scler Frontotemporal Degener. 2021 Aug;22(5-6):336-340. doi: 10.1080/21678421.2020.1867181. Epub 2021 Apr 6. Amyotroph Lateral Scler Frontotemporal Degener. 2021. PMID: 33821690 Free PMC article.
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