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Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2).
Perspicace E, Jouan-Hureaux V, Ragno R, Ballante F, Sartini S, La Motta C, Da Settimo F, Chen B, Kirsch G, Schneider S, Faivre B, Hesse S. Perspicace E, et al. Eur J Med Chem. 2013 May;63:765-81. doi: 10.1016/j.ejmech.2013.03.022. Epub 2013 Mar 19. Eur J Med Chem. 2013. PMID: 23583911
Vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors: development and validation of predictive 3-D QSAR models through extensive ligand- and structure-based approaches.
Ragno R, Ballante F, Pirolli A, Wickersham RB 3rd, Patsilinakos A, Hesse S, Perspicace E, Kirsch G. Ragno R, et al. Among authors: perspicace e. J Comput Aided Mol Des. 2015 Aug;29(8):757-76. doi: 10.1007/s10822-015-9859-y. Epub 2015 Jul 21. J Comput Aided Mol Des. 2015. PMID: 26194852
Structural optimization of 2,5-thiophene amides as highly potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.
Marchais-Oberwinkler S, Xu K, Wetzel M, Perspicace E, Negri M, Meyer A, Odermatt A, Möller G, Adamski J, Hartmann RW. Marchais-Oberwinkler S, et al. Among authors: perspicace e. J Med Chem. 2013 Jan 10;56(1):167-81. doi: 10.1021/jm3014053. Epub 2012 Dec 19. J Med Chem. 2013. PMID: 23145773
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