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Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2).
Perspicace E, Jouan-Hureaux V, Ragno R, Ballante F, Sartini S, La Motta C, Da Settimo F, Chen B, Kirsch G, Schneider S, Faivre B, Hesse S. Perspicace E, et al. Among authors: hesse s. Eur J Med Chem. 2013 May;63:765-81. doi: 10.1016/j.ejmech.2013.03.022. Epub 2013 Mar 19. Eur J Med Chem. 2013. PMID: 23583911
4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells.
Lefranc F, Xu Z, Burth P, Mathieu V, Revelant G, de Castro Faria MV, Noyon C, Garcia DG, Dufour D, Bruyère C, Gonçalves-de-Albuquerque CF, Van Antwerpen P, Rogister B, Hesse S, Kirsch G, Kiss R. Lefranc F, et al. Among authors: hesse s. Eur J Med Chem. 2013 May;63:213-23. doi: 10.1016/j.ejmech.2013.01.046. Epub 2013 Feb 16. Eur J Med Chem. 2013. PMID: 23474907
Vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors: development and validation of predictive 3-D QSAR models through extensive ligand- and structure-based approaches.
Ragno R, Ballante F, Pirolli A, Wickersham RB 3rd, Patsilinakos A, Hesse S, Perspicace E, Kirsch G. Ragno R, et al. Among authors: hesse s. J Comput Aided Mol Des. 2015 Aug;29(8):757-76. doi: 10.1007/s10822-015-9859-y. Epub 2015 Jul 21. J Comput Aided Mol Des. 2015. PMID: 26194852
428 results