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TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease.
Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume MT, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, Koganei K, Sugita A, Kanai T, Hibi T. Yoneno K, et al. Among authors: hibi t. Immunology. 2013 May;139(1):19-29. doi: 10.1111/imm.12045. Immunology. 2013. PMID: 23566200 Free PMC article. Clinical Trial.
Th1-mediated intestinal inflammation in Crohn's disease may be induced by activation of lamina propria lymphocytes through synergistic stimulation of interleukin-12 and interleukin-18 without T cell receptor engagement.
Okazawa A, Kanai T, Watanabe M, Yamazaki M, Inoue N, Ikeda M, Kurimoto M, Ishii H, Hibi T. Okazawa A, et al. Among authors: hibi t. Am J Gastroenterol. 2002 Dec;97(12):3108-17. doi: 10.1111/j.1572-0241.2002.07107.x. Am J Gastroenterol. 2002. PMID: 12492197
Dietary fat attenuates the benefits of an elemental diet in active Crohn's disease: a randomized, controlled trial.
Bamba T, Shimoyama T, Sasaki M, Tsujikawa T, Fukuda Y, Koganei K, Hibi T, Iwao Y, Munakata A, Fukuda S, Matsumoto T, Oshitani N, Hiwatashi N, Oriuchi T, Kitahora T, Utsunomiya T, Saitoh Y, Suzuki Y, Nakajima M. Bamba T, et al. Among authors: hibi t. Eur J Gastroenterol Hepatol. 2003 Feb;15(2):151-7. doi: 10.1097/00042737-200302000-00008. Eur J Gastroenterol Hepatol. 2003. PMID: 12560759 Clinical Trial.
Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice.
Ishikura T, Kanai T, Uraushihara K, Iiyama R, Makita S, Totsuka T, Yamazaki M, Sawada T, Nakamura T, Miyata T, Kitahora T, Hibi T, Hoshino T, Watanabe M. Ishikura T, et al. Among authors: hibi t. J Gastroenterol Hepatol. 2003 Aug;18(8):960-9. doi: 10.1046/j.1440-1746.2003.03097.x. J Gastroenterol Hepatol. 2003. PMID: 12859727
Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.
Kanai T, Uraushihara K, Totsuka T, Okazawa A, Hibi T, Oshima S, Miyata T, Nakamura T, Watanabe M. Kanai T, et al. Among authors: hibi t. Curr Drug Targets Inflamm Allergy. 2003 Jun;2(2):131-6. doi: 10.2174/1568010033484250. Curr Drug Targets Inflamm Allergy. 2003. PMID: 14561165 Review.
1,266 results