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Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina.
Karlstetter M, Kopatz J, Aslanidis A, Shahraz A, Caramoy A, Linnartz-Gerlach B, Lin Y, Lückoff A, Fauser S, Düker K, Claude J, Wang Y, Ackermann J, Schmidt T, Hornung V, Skerka C, Langmann T, Neumann H. Karlstetter M, et al. Among authors: luckoff a. EMBO Mol Med. 2017 Feb;9(2):154-166. doi: 10.15252/emmm.201606627. EMBO Mol Med. 2017. PMID: 28003336 Free PMC article.