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Page 1
Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4.
Reeves JT, Fandrick DR, Tan Z, Song JJ, Rodriguez S, Qu B, Kim S, Niemeier O, Li Z, Byrne D, Campbell S, Chitroda A, DeCroos P, Fachinger T, Fuchs V, Gonnella NC, Grinberg N, Haddad N, Jäger B, Lee H, Lorenz JC, Ma S, Narayanan BA, Nummy LJ, Premasiri A, Roschangar F, Sarvestani M, Shen S, Spinelli E, Sun X, Varsolona RJ, Yee N, Brenner M, Senanayake CH. Reeves JT, et al. Among authors: rodriguez s. J Org Chem. 2013 Apr 19;78(8):3616-35. doi: 10.1021/jo400079z. Epub 2013 Apr 1. J Org Chem. 2013. PMID: 23544738
Facile entry to an efficient and practical enantioselective synthesis of a polycyclic cholesteryl ester transfer protein inhibitor.
Han ZS, Xu Y, Fandrick DR, Rodriguez S, Li Z, Qu B, Gonnella NC, Sanyal S, Reeves JT, Ma S, Grinberg N, Haddad N, Krishnamurthy D, Song JJ, Yee NK, Pfrengle W, Ostermeier M, Schnaubelt J, Leuter Z, Steigmiller S, Däubler J, Stehle E, Neumann L, Trieselmann T, Tielmann P, Buba A, Hamm R, Koch G, Renner S, Dehli JR, Schmelcher F, Stange C, Mack J, Soyka R, Senanayake CH. Han ZS, et al. Among authors: rodriguez s. Org Lett. 2014 Aug 15;16(16):4142-5. doi: 10.1021/ol501833g. Epub 2014 Aug 1. Org Lett. 2014. PMID: 25084526
A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127): application of a one-pot borylation-Suzuki coupling reaction.
Zhang Y, Lu BZ, Li G, Rodriguez S, Tan J, Wei HX, Liu J, Roschangar F, Ding F, Zhao W, Qu B, Reeves D, Grinberg N, Lee H, Heckmann G, Niemeier O, Brenner M, Tsantrizos Y, Beaulieu PL, Hossain A, Yee N, Farina V, Senanayake CH. Zhang Y, et al. Among authors: rodriguez s. Org Lett. 2014 Sep 5;16(17):4558-61. doi: 10.1021/ol5021114. Epub 2014 Aug 8. Org Lett. 2014. PMID: 25105303
Development of an asymmetric synthesis of a chiral quaternary FLAP inhibitor.
Fandrick KR, Mulder JA, Patel ND, Gao J, Konrad M, Archer E, Buono FG, Duran A, Schmid R, Daeubler J, Desrosiers JN, Zeng X, Rodriguez S, Ma S, Qu B, Li Z, Fandrick DR, Grinberg N, Lee H, Bosanac T, Takahashi H, Chen Z, Bartolozzi A, Nemoto P, Busacca CA, Song JJ, Yee NK, Mahaney PE, Senanayake CH. Fandrick KR, et al. Among authors: rodriguez s. J Org Chem. 2015 Feb 6;80(3):1651-60. doi: 10.1021/jo502550h. Epub 2015 Jan 22. J Org Chem. 2015. PMID: 25562342
An Enantioselective Synthesis of an 11-β-HSD-1 Inhibitor via an Asymmetric Methallylation Catalyzed by (S)-3,3'-F2-BINOL.
Zhang Y, Wu JP, Li G, Fandrick KR, Gao J, Tan Z, Johnson J, Li W, Sanyal S, Wang J, Sun X, Lorenz JC, Rodriguez S, Reeves JT, Grinberg N, Lee H, Yee N, Lu BZ, Senanayake CH. Zhang Y, et al. Among authors: rodriguez s. J Org Chem. 2016 Mar 18;81(6):2665-9. doi: 10.1021/acs.joc.6b00189. Epub 2016 Mar 2. J Org Chem. 2016. PMID: 26909738
Development of a Scalable, Chromatography-Free Synthesis of t-Bu-SMS-Phos and Application to the Synthesis of an Important Chiral CF3-Alcohol Derivative with High Enantioselectivity Using Rh-Catalyzed Asymmetric Hydrogenation.
Sieber JD, Rodriguez S, Frutos R, Buono F, Zhang Y, Li N, Qu B, Premasiri A, Li Z, Han ZS, Xu Y, Byrne D, Haddad N, Lorenz J, Grinberg N, Kurouski D, Lee H, Narayanan B, Nummy L, Mulder J, Brown JD, Granger A, Gao J, Krawiec M, Williams Z, Pennino S, Song JJ, Hossain A, Yee NK, Busacca C, Roschangar F, Xin Y, Mao Z, Zhang X, Hong Y, Senanayake CH. Sieber JD, et al. Among authors: rodriguez s. J Org Chem. 2018 Feb 2;83(3):1448-1461. doi: 10.1021/acs.joc.7b03022. Epub 2018 Jan 23. J Org Chem. 2018. PMID: 29323903
2,330 results