Thiolation of protein-bound carcinogenic aldehyde. An electrophilic acrolein-lysine adduct that covalently binds to thiols.
Furuhata A, Nakamura M, Osawa T, Uchida K.
Furuhata A, et al. Among authors: uchida k.
J Biol Chem. 2002 Aug 2;277(31):27919-26. doi: 10.1074/jbc.M202794200. Epub 2002 May 24.
J Biol Chem. 2002.
PMID: 12032148
Free article.
Acrolein, a representative carcinogenic aldehyde that could be ubiquitously generated in biological systems under oxidative stress, shows facile reactivity with the epsilon-amino group of lysine to form N(epsilon)-(3-formyl-3,4-dehydropiperidino)lysine (FDP-lysine) as the major p …
Acrolein, a representative carcinogenic aldehyde that could be ubiquitously generated in biological systems under oxidative stress, shows fa …