Tiefenbrunn T - Search Results

1

Small molecule regulation of protein conformation by binding in the Flap of HIV protease.

Tiefenbrunn T, Forli S, Baksh MM, Chang MW, Happer M, Lin YC, Perryman AL, Rhee JK, Torbett BE, Olson AJ, Elder JH, Finn MG, Stout CD. Tiefenbrunn T, et al. ACS Chem Biol. 2013;8(6):1223-31. doi: 10.1021/cb300611p. Epub 2013 Mar 29. ACS Chem Biol. 2013. PMID: 23540839 Free PMC article.

2

Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease.

Tiefenbrunn T, Forli S, Happer M, Gonzalez A, Tsai Y, Soltis M, Elder JH, Olson AJ, Stout CD. Tiefenbrunn T, et al. Chem Biol Drug Des. 2014 Feb;83(2):141-8. doi: 10.1111/cbdd.12227. Epub 2013 Oct 30. Chem Biol Drug Des. 2014. PMID: 23998903 Free PMC article.

3

Distinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV protease.

Deng N, Forli S, He P, Perryman A, Wickstrom L, Vijayan RS, Tiefenbrunn T, Stout D, Gallicchio E, Olson AJ, Levy RM. Deng N, et al. Among authors: tiefenbrunn t. J Phys Chem B. 2015 Jan 22;119(3):976-88. doi: 10.1021/jp506376z. Epub 2014 Sep 17. J Phys Chem B. 2015. PMID: 25189630 Free PMC article.

4

High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment.

Tiefenbrunn T, Liu W, Chen Y, Katritch V, Stout CD, Fee JA, Cherezov V. Tiefenbrunn T, et al. PLoS One. 2011;6(7):e22348. doi: 10.1371/journal.pone.0022348. Epub 2011 Jul 21. PLoS One. 2011. PMID: 21814577 Free PMC article.

5

AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery.

Tsai Y, McPhillips SE, González A, McPhillips TM, Zinn D, Cohen AE, Feese MD, Bushnell D, Tiefenbrunn T, Stout CD, Ludaescher B, Hedman B, Hodgson KO, Soltis SM. Tsai Y, et al. Among authors: tiefenbrunn t. Acta Crystallogr D Biol Crystallogr. 2013 May;69(Pt 5):796-803. doi: 10.1107/S0907444913001984. Epub 2013 Apr 11. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23633588 Free PMC article.

6

Chemoselective ligation techniques: modern applications of time-honored chemistry.

Tiefenbrunn TK, Dawson PE. Tiefenbrunn TK, et al. Biopolymers. 2010;94(1):95-106. doi: 10.1002/bip.21337. Biopolymers. 2010. PMID: 20091876 Review.

7

Manipulation of thrombin exosite I, by ligand-directed covalent modification.

Yegneswaran S, Tiefenbrunn TK, Fernández JA, Dawson PE. Yegneswaran S, et al. Among authors: tiefenbrunn tk. J Thromb Haemost. 2007 Oct;5(10):2062-9. doi: 10.1111/j.1538-7836.2007.02712.x. J Thromb Haemost. 2007. PMID: 17883702 Free article.

8

Alternative chemistries for the synthesis of thrombospondin-1 type 1 repeats.

Tiefenbrunn TK, Blanco-Canosa J, Dawson PE. Tiefenbrunn TK, et al. Biopolymers. 2010;94(4):405-13. doi: 10.1002/bip.21486. Biopolymers. 2010. PMID: 20593462 Free PMC article.

9

Chemical synthesis and biotinylation of the thrombospondin domain TSR2.

Tiefenbrunn TK, Dawson PE. Tiefenbrunn TK, et al. Protein Sci. 2009 May;18(5):970-9. doi: 10.1002/pro.107. Protein Sci. 2009. PMID: 19384999 Free PMC article.

10

Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates.

Medintz IL, Clapp AR, Brunel FM, Tiefenbrunn T, Uyeda HT, Chang EL, Deschamps JR, Dawson PE, Mattoussi H. Medintz IL, et al. Among authors: tiefenbrunn t. Nat Mater. 2006 Jul;5(7):581-9. doi: 10.1038/nmat1676. Epub 2006 Jun 25. Nat Mater. 2006. PMID: 16799548

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