Kampourakis T - Search Results

1

Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease.

Toepfer C, Caorsi V, Kampourakis T, Sikkel MB, West TG, Leung MC, Al-Saud SA, MacLeod KT, Lyon AR, Marston SB, Sellers JR, Ferenczi MA. Toepfer C, et al. Among authors: kampourakis t. J Biol Chem. 2013 May 10;288(19):13446-54. doi: 10.1074/jbc.M113.455444. Epub 2013 Mar 25. J Biol Chem. 2013. PMID: 23530050 Free PMC article.

2

Orientation of the N- and C-terminal lobes of the myosin regulatory light chain in cardiac muscle.

Kampourakis T, Sun YB, Irving M. Kampourakis T, et al. Biophys J. 2015 Jan 20;108(2):304-14. doi: 10.1016/j.bpj.2014.11.049. Biophys J. 2015. PMID: 25606679 Free PMC article.

3

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle.

Kampourakis T, Irving M. Kampourakis T, et al. J Mol Cell Cardiol. 2015 Aug;85:199-206. doi: 10.1016/j.yjmcc.2015.06.002. Epub 2015 Jun 7. J Mol Cell Cardiol. 2015. PMID: 26057075 Free PMC article.

4

Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments.

Kampourakis T, Sun YB, Irving M. Kampourakis T, et al. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3039-47. doi: 10.1073/pnas.1602776113. Epub 2016 May 9. Proc Natl Acad Sci U S A. 2016. PMID: 27162358 Free PMC article.

5

Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle.

Kampourakis T, Ponnam S, Irving M. Kampourakis T, et al. J Mol Cell Cardiol. 2018 Apr;117:72-81. doi: 10.1016/j.yjmcc.2018.02.009. Epub 2018 Feb 13. J Mol Cell Cardiol. 2018. PMID: 29452157 Free PMC article.

6

Structural and functional effects of myosin-binding protein-C phosphorylation in heart muscle are not mimicked by serine-to-aspartate substitutions.

Kampourakis T, Ponnam S, Sun YB, Sevrieva I, Irving M. Kampourakis T, et al. J Biol Chem. 2018 Sep 14;293(37):14270-14275. doi: 10.1074/jbc.AC118.004816. Epub 2018 Aug 6. J Biol Chem. 2018. PMID: 30082313 Free PMC article.

7

Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I.

Sevrieva IR, Brandmeier B, Ponnam S, Gautel M, Irving M, Campbell KS, Sun YB, Kampourakis T. Sevrieva IR, et al. Among authors: kampourakis t. J Biol Chem. 2020 Apr 3;295(14):4398-4410. doi: 10.1074/jbc.RA119.011945. Epub 2020 Feb 21. J Biol Chem. 2020. PMID: 32086378 Free PMC article.

8

The regulatory light chain mediates inactivation of myosin motors during active shortening of cardiac muscle.

Kampourakis T, Irving M. Kampourakis T, et al. Nat Commun. 2021 Sep 6;12(1):5272. doi: 10.1038/s41467-021-25601-8. Nat Commun. 2021. PMID: 34489440 Free PMC article.

9

Microscale thermophoresis suggests a new model of regulation of cardiac myosin function via interaction with cardiac myosin-binding protein C.

Ponnam S, Kampourakis T. Ponnam S, et al. Among authors: kampourakis t. J Biol Chem. 2022 Jan;298(1):101485. doi: 10.1016/j.jbc.2021.101485. Epub 2021 Dec 14. J Biol Chem. 2022. PMID: 34915024 Free PMC article.

10

Phosphorylation-dependent interactions of myosin-binding protein C and troponin coordinate the myofilament response to protein kinase A.

Sevrieva IR, Ponnam S, Yan Z, Irving M, Kampourakis T, Sun YB. Sevrieva IR, et al. Among authors: kampourakis t. J Biol Chem. 2023 Jan;299(1):102767. doi: 10.1016/j.jbc.2022.102767. Epub 2022 Dec 5. J Biol Chem. 2023. PMID: 36470422 Free PMC article.

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