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Page 1
Target validation using chemical probes.
Bunnage ME, Chekler EL, Jones LH. Bunnage ME, et al. Among authors: chekler el. Nat Chem Biol. 2013 Apr;9(4):195-9. doi: 10.1038/nchembio.1197. Nat Chem Biol. 2013. PMID: 23508172 No abstract available.
Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators.
Unwalla R, Mousseau JJ, Fadeyi OO, Choi C, Parris K, Hu B, Kenney T, Chippari S, McNally C, Vishwanathan K, Kilbourne E, Thompson C, Nagpal S, Wrobel J, Yudt M, Morris CA, Powell D, Gilbert AM, Chekler ELP. Unwalla R, et al. Among authors: chekler elp. J Med Chem. 2017 Jul 27;60(14):6451-6457. doi: 10.1021/acs.jmedchem.7b00373. Epub 2017 Jul 11. J Med Chem. 2017. PMID: 28696695
Synthesis and SAR development of quinoline analogs as novel P2X7 receptor antagonists.
Xiao Y, Karra S, Goutopoulos A, Morse NT, Zhang S, Dhanabal M, Tian H, Seenisamy J, Jayadevan J, Caldwell R, Potnick J, Bleich M, Chekler E, Sherer B, Sriraman V. Xiao Y, et al. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1660-1664. doi: 10.1016/j.bmcl.2019.04.033. Epub 2019 Apr 24. Bioorg Med Chem Lett. 2019. PMID: 31031055
Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy.
Chekler EL, Kiselyov AS, Ouyang X, Chen X, Pattaropong V, Wang Y, Tuma MC, Doody JF. Chekler EL, et al. ACS Med Chem Lett. 2010 Aug 20;1(9):488-92. doi: 10.1021/ml1001568. eCollection 2010 Dec 9. ACS Med Chem Lett. 2010. PMID: 24900236 Free PMC article.
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.
Schindler CEM, Baumann H, Blum A, Böse D, Buchstaller HP, Burgdorf L, Cappel D, Chekler E, Czodrowski P, Dorsch D, Eguida MKI, Follows B, Fuchß T, Grädler U, Gunera J, Johnson T, Jorand Lebrun C, Karra S, Klein M, Knehans T, Koetzner L, Krier M, Leiendecker M, Leuthner B, Li L, Mochalkin I, Musil D, Neagu C, Rippmann F, Schiemann K, Schulz R, Steinbrecher T, Tanzer EM, Unzue Lopez A, Viacava Follis A, Wegener A, Kuhn D. Schindler CEM, et al. J Chem Inf Model. 2020 Nov 23;60(11):5457-5474. doi: 10.1021/acs.jcim.0c00900. Epub 2020 Sep 3. J Chem Inf Model. 2020. PMID: 32813975
Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A.
Alexander MS, Gasperini MJ, Tsai PT, Gibbs DE, Spinazzola JM, Marshall JL, Feyder MJ, Pletcher MT, Chekler EL, Morris CA, Sahin M, Harms JF, Schmidt CJ, Kleiman RJ, Kunkel LM. Alexander MS, et al. Among authors: chekler el. Transl Psychiatry. 2016 Sep 27;6(9):e901. doi: 10.1038/tp.2016.174. Transl Psychiatry. 2016. PMID: 27676442 Free PMC article.
Antitumor Activity of IMC-038525, a Novel Oral Tubulin Polymerization Inhibitor.
Tuma MC, Malikzay A, Ouyang X, Surguladze D, Fleming J, Mitelman S, Camara M, Finnerty B, Doody J, Chekler EL, Kussie P, Tonra JR. Tuma MC, et al. Among authors: chekler el. Transl Oncol. 2010 Oct 1;3(5):318-25. doi: 10.1593/tlo.10160. Transl Oncol. 2010. PMID: 20885894 Free PMC article.