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Immunogenicity, efficacy, safety, and mechanism of action of epitope vaccine (Lu AF20513) for Alzheimer's disease: prelude to a clinical trial.
Davtyan H, Ghochikyan A, Petrushina I, Hovakimyan A, Davtyan A, Poghosyan A, Marleau AM, Movsesyan N, Kiyatkin A, Rasool S, Larsen AK, Madsen PJ, Wegener KM, Ditlevsen DK, Cribbs DH, Pedersen LO, Agadjanyan MG. Davtyan H, et al. Among authors: kiyatkin a. J Neurosci. 2013 Mar 13;33(11):4923-34. doi: 10.1523/JNEUROSCI.4672-12.2013. J Neurosci. 2013. PMID: 23486963 Free PMC article.
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.
Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan N, Mina E, Kiyatkin A, Glabe CG, Cribbs DH, Agadjanyan MG. Mamikonyan G, et al. Among authors: kiyatkin a. J Biol Chem. 2007 Aug 3;282(31):22376-86. doi: 10.1074/jbc.M700088200. Epub 2007 Jun 1. J Biol Chem. 2007. PMID: 17545160 Free PMC article.
Refinement of a DNA based Alzheimer's disease epitope vaccine in rabbits.
Ghochikyan A, Davtyan H, Petrushina I, Hovakimyan A, Movsesyan N, Davtyan A, Kiyatkin A, Cribbs DH, Agadjanyan MG. Ghochikyan A, et al. Among authors: kiyatkin a. Hum Vaccin Immunother. 2013 May;9(5):1002-10. doi: 10.4161/hv.23875. Epub 2013 Feb 11. Hum Vaccin Immunother. 2013. PMID: 23399748 Free PMC article.
Tyr-317 phosphorylation increases Shc structural rigidity and reduces coupling of domain motions remote from the phosphorylation site as revealed by molecular dynamics simulations.
Suenaga A, Kiyatkin AB, Hatakeyama M, Futatsugi N, Okimoto N, Hirano Y, Narumi T, Kawai A, Susukita R, Koishi T, Furusawa H, Yasuoka K, Takada N, Ohno Y, Taiji M, Ebisuzaki T, Hoek JB, Konagaya A, Kholodenko BN. Suenaga A, et al. Among authors: kiyatkin ab. J Biol Chem. 2004 Feb 6;279(6):4657-62. doi: 10.1074/jbc.M310598200. Epub 2003 Nov 12. J Biol Chem. 2004. PMID: 14613932 Free article.
35 results