Brun R - Search Results

1

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT).

Hwang JY, Smithson D, Zhu F, Holbrook G, Connelly MC, Kaiser M, Brun R, Guy RK. Hwang JY, et al. Among authors: brun r. J Med Chem. 2013 Apr 11;56(7):2850-60. doi: 10.1021/jm301687p. Epub 2013 Mar 26. J Med Chem. 2013. PMID: 23484493

2

Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models.

Mallari JP, Zhu F, Lemoff A, Kaiser M, Lu M, Brun R, Guy RK. Mallari JP, et al. Among authors: brun r. Bioorg Med Chem. 2010 Dec 1;18(23):8302-9. doi: 10.1016/j.bmc.2010.09.073. Epub 2010 Oct 8. Bioorg Med Chem. 2010. PMID: 21051236

3

Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei.

Hwang JY, Smithson DC, Holbrook G, Zhu F, Connelly MC, Kaiser M, Brun R, Kiplin Guy R. Hwang JY, et al. Among authors: brun r. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4127-31. doi: 10.1016/j.bmcl.2013.05.049. Epub 2013 May 23. Bioorg Med Chem Lett. 2013. PMID: 23746473

4

DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.

Dardonville C, Barrett MP, Brun R, Kaiser M, Tanious F, Wilson WD. Dardonville C, et al. Among authors: brun r. J Med Chem. 2006 Jun 15;49(12):3748-52. doi: 10.1021/jm060295c. J Med Chem. 2006. PMID: 16759117 Free article.

5

New bis(2-aminoimidazoline) and bisguanidine DNA minor groove binders with potent in vivo antitrypanosomal and antiplasmodial activity.

Rodríguez F, Rozas I, Kaiser M, Brun R, Nguyen B, Wilson WD, García RN, Dardonville C. Rodríguez F, et al. Among authors: brun r. J Med Chem. 2008 Feb 28;51(4):909-23. doi: 10.1021/jm7013088. Epub 2008 Feb 5. J Med Chem. 2008. PMID: 18247550

6

Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites.

Link A, Heidler P, Kaiser M, Brun R. Link A, et al. Among authors: brun r. Eur J Med Chem. 2009 Sep;44(9):3665-71. doi: 10.1016/j.ejmech.2009.02.010. Epub 2009 Feb 20. Eur J Med Chem. 2009. PMID: 19285758

7

Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability.

Nieto L, Mascaraque A, Miller F, Glacial F, Ríos Martínez C, Kaiser M, Brun R, Dardonville C. Nieto L, et al. Among authors: brun r. J Med Chem. 2011 Jan 27;54(2):485-94. doi: 10.1021/jm101335q. Epub 2010 Dec 22. J Med Chem. 2011. PMID: 21175162

8

1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis.

Trunz BB, Jędrysiak R, Tweats D, Brun R, Kaiser M, Suwiński J, Torreele E. Trunz BB, et al. Among authors: brun r. Eur J Med Chem. 2011 May;46(5):1524-35. doi: 10.1016/j.ejmech.2011.01.071. Epub 2011 Feb 26. Eur J Med Chem. 2011. PMID: 21353728

9

Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.

Papadopoulou MV, Trunz BB, Bloomer WD, McKenzie C, Wilkinson SR, Prasittichai C, Brun R, Kaiser M, Torreele E. Papadopoulou MV, et al. Among authors: brun r. J Med Chem. 2011 Dec 8;54(23):8214-23. doi: 10.1021/jm201215n. Epub 2011 Nov 4. J Med Chem. 2011. PMID: 22023653 Free PMC article.

10

Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.

Karaaslan C, Kaiser M, Brun R, Göker H. Karaaslan C, et al. Among authors: brun r. Bioorg Med Chem. 2016 Sep 15;24(18):4038-4044. doi: 10.1016/j.bmc.2016.06.047. Epub 2016 Jun 25. Bioorg Med Chem. 2016. PMID: 27387356

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