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A new anti-human Fc method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in serum from pre-clinical species.
Excoffier M, Janin-Bussat MC, Beau-Larvor C, Troncy L, Corvaia N, Beck A, Klinguer-Hamour C. Excoffier M, et al. Among authors: janin bussat mc. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:149-154. doi: 10.1016/j.jchromb.2016.05.037. Epub 2016 May 24. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27267073
Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. II- Identification of sub-units for the characterization of even and odd load drug species.
Sarrut M, Fekete S, Janin-Bussat MC, Colas O, Guillarme D, Beck A, Heinisch S. Sarrut M, et al. Among authors: janin bussat mc. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:91-102. doi: 10.1016/j.jchromb.2016.06.049. Epub 2016 Jun 28. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27426265
Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. I - Optimization of separation conditions.
Sarrut M, Corgier A, Fekete S, Guillarme D, Lascoux D, Janin-Bussat MC, Beck A, Heinisch S. Sarrut M, et al. Among authors: janin bussat mc. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:103-111. doi: 10.1016/j.jchromb.2016.06.048. Epub 2016 Jun 28. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27426266