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Page 1
Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Hubbard BP, et al. Among authors: lamming dw. Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097. Science. 2013. PMID: 23471411 Free PMC article.
Dietary lipid is largely deposited in skin and rapidly affects insulating properties.
Riley N, Kasza I, Hermsmeyer IDK, Trautman ME, Barrett-Wilt G, Jain R, Simcox JA, Yen CE, MacDougald OA, Lamming DW, Alexander CM. Riley N, et al. Among authors: lamming dw. Res Sq [Preprint]. 2024 Oct 7:rs.3.rs-3957002. doi: 10.21203/rs.3.rs-3957002/v1. Res Sq. 2024. PMID: 38464106 Free PMC article. Preprint.
Blazing a trail for the clinical use of rapamycin as a geroprotecTOR.
Konopka AR, Lamming DW; RAP PAC Investigators; EVERLAST Investigators. Konopka AR, et al. Among authors: lamming dw. Geroscience. 2023 Oct;45(5):2769-2783. doi: 10.1007/s11357-023-00935-x. Epub 2023 Oct 6. Geroscience. 2023. PMID: 37801202 Free PMC article.
Late-life isoleucine restriction promotes physiological and molecular signatures of healthy aging.
Yeh CY, Chini LCS, Davidson JW, Garcia GG, Gallagher MS, Freichels IT, Calubag MF, Rodgers AC, Green CL, Babygirija R, Sonsalla MM, Pak HH, Trautman M, Hacker TA, Miller RA, Simcox J, Lamming DW. Yeh CY, et al. Among authors: lamming dw. bioRxiv [Preprint]. 2024 Jan 9:2023.02.06.527311. doi: 10.1101/2023.02.06.527311. bioRxiv. 2024. Update in: Nat Aging. 2024 Dec;4(12):1760-1771. doi: 10.1038/s43587-024-00744-7 PMID: 36798157 Free PMC article. Updated. Preprint.
Targeting the biology of aging with mTOR inhibitors.
Mannick JB, Lamming DW. Mannick JB, et al. Among authors: lamming dw. Nat Aging. 2023 Jun;3(6):642-660. doi: 10.1038/s43587-023-00416-y. Epub 2023 May 4. Nat Aging. 2023. PMID: 37142830 Free PMC article. Review.
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging.
Mihaylova MM, Chaix A, Delibegovic M, Ramsey JJ, Bass J, Melkani G, Singh R, Chen Z, Ja WW, Shirasu-Hiza M, Latimer MN, Mattison JA, Thalacker-Mercer AE, Dixit VD, Panda S, Lamming DW. Mihaylova MM, et al. Among authors: lamming dw. Cell Metab. 2023 Jul 11;35(7):1114-1131. doi: 10.1016/j.cmet.2023.06.008. Epub 2023 Jun 30. Cell Metab. 2023. PMID: 37392742 Free PMC article. Review.
Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice.
Green CL, Trautman ME, Chaiyakul K, Jain R, Alam YH, Babygirija R, Pak HH, Sonsalla MM, Calubag MF, Yeh CY, Bleicher A, Novak G, Liu TT, Newman S, Ricke WA, Matkowskyj KA, Ong IM, Jang C, Simcox J, Lamming DW. Green CL, et al. Among authors: lamming dw. Cell Metab. 2023 Nov 7;35(11):1976-1995.e6. doi: 10.1016/j.cmet.2023.10.005. Cell Metab. 2023. PMID: 37939658 Free PMC article.
Dietary isoleucine content defines the metabolic and molecular response to a Western diet.
Trautman ME, Green CL, MacArthur MR, Chaiyakul K, Alam YH, Yeh CY, Babygirija R, James I, Gilpin M, Zelenovskiy E, Green M, Marshall RN, Sonsalla MM, Flores V, Simcox JA, Ong IM, Malecki KC, Jang C, Lamming DW. Trautman ME, et al. Among authors: lamming dw. bioRxiv [Preprint]. 2024 Jun 3:2024.05.30.596340. doi: 10.1101/2024.05.30.596340. bioRxiv. 2024. PMID: 38895446 Free PMC article. Preprint.
121 results