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Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA. Hubbard BP, et al. Among authors: dai h. Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097. Science. 2013. PMID: 23471411 Free PMC article.
Synthesis and Assay of SIRT1-Activating Compounds.
Dai H, Ellis JL, Sinclair DA, Hubbard BP. Dai H, et al. Methods Enzymol. 2016;574:213-244. doi: 10.1016/bs.mie.2016.01.012. Epub 2016 Feb 9. Methods Enzymol. 2016. PMID: 27423864 Free PMC article.
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Dai H, Case AW, Riera TV, Considine T, Lee JE, Hamuro Y, Zhao H, Jiang Y, Sweitzer SM, Pietrak B, Schwartz B, Blum CA, Disch JS, Caldwell R, Szczepankiewicz B, Oalmann C, Yee Ng P, White BH, Casaubon R, Narayan R, Koppetsch K, Bourbonais F, Wu B, Wang J, Qian D, Jiang F, Mao C, Wang M, Hu E, Wu JC, Perni RB, Vlasuk GP, Ellis JL. Dai H, et al. Nat Commun. 2015 Jul 2;6:7645. doi: 10.1038/ncomms8645. Nat Commun. 2015. PMID: 26134520 Free PMC article.
Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) Demonstrates That Sleep Disorders Exacerbate Glymphatic Circulatory Impairment and Cognitive Impairment in Patients with Alzheimer's Disease.
Shang Y, Yu L, Xing H, Chang Y, Dong K, Xiao Y, Liu Y, Feng M, Qin Y, Dai H. Shang Y, et al. Among authors: dai h. Nat Sci Sleep. 2024 Dec 23;16:2205-2215. doi: 10.2147/NSS.S496607. eCollection 2024. Nat Sci Sleep. 2024. PMID: 39735385 Free PMC article.
6,703 results