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The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies.
Gierer S, Bertram S, Kaup F, Wrensch F, Heurich A, Krämer-Kühl A, Welsch K, Winkler M, Meyer B, Drosten C, Dittmer U, von Hahn T, Simmons G, Hofmann H, Pöhlmann S. Gierer S, et al. Among authors: pohlmann s. J Virol. 2013 May;87(10):5502-11. doi: 10.1128/JVI.00128-13. Epub 2013 Mar 6. J Virol. 2013. PMID: 23468491 Free PMC article.
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.
Hofmann H, Geier M, Marzi A, Krumbiegel M, Peipp M, Fey GH, Gramberg T, Pöhlmann S. Hofmann H, et al. Among authors: pohlmann s. Biochem Biophys Res Commun. 2004 Jul 9;319(4):1216-21. doi: 10.1016/j.bbrc.2004.05.114. Biochem Biophys Res Commun. 2004. PMID: 15194496 Free PMC article.
Cellular entry of the SARS coronavirus.
Hofmann H, Pöhlmann S. Hofmann H, et al. Among authors: pohlmann s. Trends Microbiol. 2004 Oct;12(10):466-72. doi: 10.1016/j.tim.2004.08.008. Trends Microbiol. 2004. PMID: 15381196 Free PMC article. Review.
DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus.
Marzi A, Gramberg T, Simmons G, Möller P, Rennekamp AJ, Krumbiegel M, Geier M, Eisemann J, Turza N, Saunier B, Steinkasserer A, Becker S, Bates P, Hofmann H, Pöhlmann S. Marzi A, et al. Among authors: pohlmann s. J Virol. 2004 Nov;78(21):12090-5. doi: 10.1128/JVI.78.21.12090-12095.2004. J Virol. 2004. PMID: 15479853 Free PMC article.
331 results