Chikumi H - Search Results

1

PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.

Mikelis CM, Palmby TR, Simaan M, Li W, Szabo R, Lyons R, Martin D, Yagi H, Fukuhara S, Chikumi H, Galisteo R, Mukouyama YS, Bugge TH, Gutkind JS. Mikelis CM, et al. Among authors: chikumi h. J Biol Chem. 2013 Apr 26;288(17):12232-43. doi: 10.1074/jbc.M112.428599. Epub 2013 Mar 6. J Biol Chem. 2013. PMID: 23467409 Free PMC article.

2

Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase.

Chikumi H, Fukuhara S, Gutkind JS. Chikumi H, et al. J Biol Chem. 2002 Apr 5;277(14):12463-73. doi: 10.1074/jbc.M108504200. Epub 2002 Jan 17. J Biol Chem. 2002. PMID: 11799111 Free article.

3

Potent activation of RhoA by Galpha q and Gq-coupled receptors.

Chikumi H, Vázquez-Prado J, Servitja JM, Miyazaki H, Gutkind JS. Chikumi H, et al. J Biol Chem. 2002 Jul 26;277(30):27130-4. doi: 10.1074/jbc.M204715200. Epub 2002 May 16. J Biol Chem. 2002. PMID: 12016230 Free article.

4

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.

Fukuhara S, Chikumi H, Gutkind JS. Fukuhara S, et al. Among authors: chikumi h. FEBS Lett. 2000 Nov 24;485(2-3):183-8. doi: 10.1016/s0014-5793(00)02224-9. FEBS Lett. 2000. PMID: 11094164 Free article.

5

Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential.

Chikumi H, Barac A, Behbahani B, Gao Y, Teramoto H, Zheng Y, Gutkind JS. Chikumi H, et al. Oncogene. 2004 Jan 8;23(1):233-40. doi: 10.1038/sj.onc.1207012. Oncogene. 2004. PMID: 14712228

6

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

Fukuhara S, Chikumi H, Gutkind JS. Fukuhara S, et al. Among authors: chikumi h. Oncogene. 2001 Mar 26;20(13):1661-8. doi: 10.1038/sj.onc.1204182. Oncogene. 2001. PMID: 11313914 Review. No abstract available.

7

Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases.

Longenecker KL, Lewis ME, Chikumi H, Gutkind JS, Derewenda ZS. Longenecker KL, et al. Among authors: chikumi h. Structure. 2001 Jul 3;9(7):559-69. doi: 10.1016/s0969-2126(01)00620-7. Structure. 2001. PMID: 11470431 Free article.

8

Potent transforming activity of the small GTP-binding protein Rit in NIH 3T3 cells: evidence for a role of a p38gamma-dependent signaling pathway.

Sakabe K, Teramoto H, Zohar M, Behbahani B, Miyazaki H, Chikumi H, Gutkind JS. Sakabe K, et al. Among authors: chikumi h. FEBS Lett. 2002 Jan 30;511(1-3):15-20. doi: 10.1016/s0014-5793(01)03264-1. FEBS Lett. 2002. PMID: 11821041 Free article.

9

Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors.

Touge H, Chikumi H, Igishi T, Kurai J, Makino H, Tamura Y, Takata M, Yoneda K, Nakamoto M, Suyama H, Gutkind JS, Shimizu E. Touge H, et al. Among authors: chikumi h. Int J Oncol. 2007 Mar;30(3):709-15. Int J Oncol. 2007. PMID: 17273773

10

Rapamycin induces p53-independent apoptosis through the mitochondrial pathway in non-small cell lung cancer cells.

Miyake N, Chikumi H, Takata M, Nakamoto M, Igishi T, Shimizu E. Miyake N, et al. Among authors: chikumi h. Oncol Rep. 2012 Sep;28(3):848-54. doi: 10.3892/or.2012.1855. Epub 2012 Jun 12. Oncol Rep. 2012. PMID: 22710790

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