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Simplified silvestrol analogues with potent cytotoxic activity.
Hawkins BC, Lindqvist LM, Nhu D, Sharp PP, Segal D, Powell AK, Campbell M, Ryan E, Chambers JM, White JM, Rizzacasa MA, Lessene G, Huang DC, Burns CJ. Hawkins BC, et al. Among authors: chambers jm. ChemMedChem. 2014 Jul;9(7):1556-66. doi: 10.1002/cmdc.201400024. Epub 2014 Mar 27. ChemMedChem. 2014. PMID: 24677741
Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor.
Lindqvist LM, Vikström I, Chambers JM, McArthur K, Ann Anderson M, Henley KJ, Happo L, Cluse L, Johnstone RW, Roberts AW, Kile BT, Croker BA, Burns CJ, Rizzacasa MA, Strasser A, Huang DC. Lindqvist LM, et al. Among authors: chambers jm. Cell Death Dis. 2012 Oct 11;3(10):e409. doi: 10.1038/cddis.2012.149. Cell Death Dis. 2012. PMID: 23059828 Free PMC article.
Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.
Saunders EC, Ng WW, Chambers JM, Ng M, Naderer T, Krömer JO, Likic VA, McConville MJ. Saunders EC, et al. Among authors: chambers jm. J Biol Chem. 2011 Aug 5;286(31):27706-17. doi: 10.1074/jbc.M110.213553. Epub 2011 Jun 2. J Biol Chem. 2011. PMID: 21636575 Free PMC article.
Benchmarking Refined and Unrefined AlphaFold2 Structures for Hit Discovery.
Zhang Y, Vass M, Shi D, Abualrous E, Chambers JM, Chopra N, Higgs C, Kasavajhala K, Li H, Nandekar P, Sato H, Miller EB, Repasky MP, Jerome SV. Zhang Y, et al. Among authors: chambers jm. J Chem Inf Model. 2023 Mar 27;63(6):1656-1667. doi: 10.1021/acs.jcim.2c01219. Epub 2023 Mar 10. J Chem Inf Model. 2023. PMID: 36897766
47 results