Pisani L - Search Results

1

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.

Pisani L, Barletta M, Soto-Otero R, Nicolotti O, Mendez-Alvarez E, Catto M, Introcaso A, Stefanachi A, Cellamare S, Altomare C, Carotti A. Pisani L, et al. J Med Chem. 2013 Mar 28;56(6):2651-64. doi: 10.1021/jm4000769. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23437843

2

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.

Leonetti F, Capaldi C, Pisani L, Nicolotti O, Muncipinto G, Stefanachi A, Cellamare S, Caccia C, Carotti A. Leonetti F, et al. Among authors: pisani l. J Med Chem. 2007 Oct 4;50(20):4909-16. doi: 10.1021/jm070725e. Epub 2007 Sep 7. J Med Chem. 2007. PMID: 17824599

3

Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs.

Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A. Binda C, et al. Among authors: pisani l. J Med Chem. 2007 Nov 15;50(23):5848-52. doi: 10.1021/jm070677y. Epub 2007 Oct 4. J Med Chem. 2007. PMID: 17915852

4

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.

Leonetti F, Catto M, Nicolotti O, Pisani L, Cappa A, Stefanachi A, Carotti A. Leonetti F, et al. Among authors: pisani l. Bioorg Med Chem. 2008 Aug 1;16(15):7450-6. doi: 10.1016/j.bmc.2008.06.022. Epub 2008 Jun 14. Bioorg Med Chem. 2008. PMID: 18585045

5

Discovery of a novel class of potent coumarin monoamine oxidase B inhibitors: development and biopharmacological profiling of 7-[(3-chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a highly potent, selective, reversible, and orally active monoamine oxidase B inhibitor.

Pisani L, Muncipinto G, Miscioscia TF, Nicolotti O, Leonetti F, Catto M, Caccia C, Salvati P, Soto-Otero R, Mendez-Alvarez E, Passeleu C, Carotti A. Pisani L, et al. J Med Chem. 2009 Nov 12;52(21):6685-706. doi: 10.1021/jm9010127. J Med Chem. 2009. PMID: 19810674

6

Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model.

Nicolotti O, Giangreco I, Miscioscia TF, Convertino M, Leonetti F, Pisani L, Carotti A. Nicolotti O, et al. Among authors: pisani l. J Comput Aided Mol Des. 2010 Feb;24(2):117-29. doi: 10.1007/s10822-010-9320-1. Epub 2010 Feb 11. J Comput Aided Mol Des. 2010. PMID: 20148287

7

Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors.

Pisani L, Catto M, Giangreco I, Leonetti F, Nicolotti O, Stefanachi A, Cellamare S, Carotti A. Pisani L, et al. ChemMedChem. 2010 Sep 3;5(9):1616-30. doi: 10.1002/cmdc.201000210. ChemMedChem. 2010. PMID: 20677317

8

Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.

Stefanachi A, Favia AD, Nicolotti O, Leonetti F, Pisani L, Catto M, Zimmer C, Hartmann RW, Carotti A. Stefanachi A, et al. Among authors: pisani l. J Med Chem. 2011 Mar 24;54(6):1613-25. doi: 10.1021/jm101120u. Epub 2011 Feb 22. J Med Chem. 2011. PMID: 21341743

9

Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.

Conejo-García A, Pisani L, Núñez Mdel C, Catto M, Nicolotti O, Leonetti F, Campos JM, Gallo MA, Espinosa A, Carotti A. Conejo-García A, et al. Among authors: pisani l. J Med Chem. 2011 Apr 28;54(8):2627-45. doi: 10.1021/jm101299d. Epub 2011 Apr 6. J Med Chem. 2011. PMID: 21417225

10

Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.

Tasso B, Catto M, Nicolotti O, Novelli F, Tonelli M, Giangreco I, Pisani L, Sparatore A, Boido V, Carotti A, Sparatore F. Tasso B, et al. Among authors: pisani l. Eur J Med Chem. 2011 Jun;46(6):2170-84. doi: 10.1016/j.ejmech.2011.02.071. Epub 2011 Mar 5. Eur J Med Chem. 2011. PMID: 21459491

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