Hanessian S - Search Results

1

Crystal structures of a bioactive 6'-hydroxy variant of sisomicin bound to the bacterial and protozoal ribosomal decoding sites.

Kondo J, Koganei M, Maianti JP, Ly VL, Hanessian S. Kondo J, et al. Among authors: hanessian s. ChemMedChem. 2013 May;8(5):733-9. doi: 10.1002/cmdc.201200579. Epub 2013 Feb 21. ChemMedChem. 2013. PMID: 23436717

2

Structure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside.

Kanazawa H, Saavedra OM, Maianti JP, Young SA, Izquierdo L, Smith TK, Hanessian S, Kondo J. Kanazawa H, et al. Among authors: hanessian s. ChemMedChem. 2018 Aug 10;13(15):1541-1548. doi: 10.1002/cmdc.201800166. Epub 2018 Jul 4. ChemMedChem. 2018. PMID: 29766661

3

Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity.

Kondo J, Pachamuthu K, François B, Szychowski J, Hanessian S, Westhof E. Kondo J, et al. Among authors: hanessian s. ChemMedChem. 2007 Nov;2(11):1631-8. doi: 10.1002/cmdc.200700113. ChemMedChem. 2007. PMID: 17722211

4

Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues.

Szychowski J, Kondo J, Zahr O, Auclair K, Westhof E, Hanessian S, Keillor JW. Szychowski J, et al. Among authors: hanessian s. ChemMedChem. 2011 Nov 4;6(11):1961-6. doi: 10.1002/cmdc.201100346. Epub 2011 Sep 8. ChemMedChem. 2011. PMID: 21905229 Free PMC article.

5

Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin.

Hanessian S, Maianti JP. Hanessian S, et al. Chem Commun (Camb). 2010 Mar 28;46(12):2013-5. doi: 10.1039/b925668g. Epub 2010 Feb 15. Chem Commun (Camb). 2010. PMID: 20221476

6

Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial neomycin analogs.

Maianti JP, Kanazawa H, Dozzo P, Matias RD, Feeney LA, Armstrong ES, Hildebrandt DJ, Kane TR, Gliedt MJ, Goldblum AA, Linsell MS, Aggen JB, Kondo J, Hanessian S. Maianti JP, et al. Among authors: hanessian s. ACS Chem Biol. 2014 Sep 19;9(9):2067-73. doi: 10.1021/cb5003416. Epub 2014 Jul 14. ACS Chem Biol. 2014. PMID: 25019242

7

Hybrid aminoglycoside antibiotics via Tsuji palladium-catalyzed allylic deoxygenation.

Hanessian S, Maianti JP, Matias RD, Feeney LA, Armstrong ES. Hanessian S, et al. Org Lett. 2011 Dec 16;13(24):6476-9. doi: 10.1021/ol2027703. Epub 2011 Nov 15. Org Lett. 2011. PMID: 22085292

8

Synthesis and comparative antibacterial activity of verdamicin C2 and C2a. A new oxidation of primary allylic azides in dihydro[2H]pyrans.

Hanessian S, Szychowski J, Maianti JP. Hanessian S, et al. Org Lett. 2009 Jan 15;11(2):429-32. doi: 10.1021/ol802421d. Org Lett. 2009. PMID: 19072132

9

Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.

Hanessian S, Szychowski J, Adhikari SS, Vasquez G, Kandasamy P, Swayze EE, Migawa MT, Ranken R, François B, Wirmer-Bartoschek J, Kondo J, Westhof E. Hanessian S, et al. J Med Chem. 2007 May 17;50(10):2352-69. doi: 10.1021/jm061200+. Epub 2007 Apr 26. J Med Chem. 2007. PMID: 17458946

10

Total Synthesis of Isodaphlongamine H: A Possible Biogenetic Conundrum.

Chattopadhyay AK, Ly VL, Jakkepally S, Berger G, Hanessian S. Chattopadhyay AK, et al. Among authors: hanessian s. Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2577-81. doi: 10.1002/anie.201510861. Epub 2016 Jan 14. Angew Chem Int Ed Engl. 2016. PMID: 26765928

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