Tokuyama H - Search Results

1

The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.

Hasegawa K, Wakino S, Kimoto M, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Tokuyama H, Hayashi K, Itoh H. Hasegawa K, et al. Among authors: tokuyama h. FASEB J. 2013 Jun;27(6):2301-15. doi: 10.1096/fj.12-226092. Epub 2013 Feb 21. FASEB J. 2013. PMID: 23430976

2

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.

Hasegawa K, Wakino S, Simic P, Sakamaki Y, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Kubota E, Tokuyama H, Hayashi K, Guarente L, Itoh H. Hasegawa K, et al. Among authors: tokuyama h. Nat Med. 2013 Nov;19(11):1496-504. doi: 10.1038/nm.3363. Epub 2013 Oct 20. Nat Med. 2013. PMID: 24141423 Free PMC article.

3

Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans.

Hosoya K, Minakuchi H, Wakino S, Fujimura K, Hasegawa K, Komatsu M, Yoshifuji A, Futatsugi K, Shinozuka K, Washida N, Kanda T, Tokuyama H, Hayashi K, Itoh H. Hosoya K, et al. Among authors: tokuyama h. Kidney Int. 2015 Apr;87(4):749-60. doi: 10.1038/ki.2014.348. Epub 2014 Oct 22. Kidney Int. 2015. PMID: 25337775 Free article. Clinical Trial.

4

Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression.

Hasegawa K, Wakino S, Yoshioka K, Tatematsu S, Hara Y, Minakuchi H, Washida N, Tokuyama H, Hayashi K, Itoh H. Hasegawa K, et al. Among authors: tokuyama h. Biochem Biophys Res Commun. 2008 Jul 18;372(1):51-6. doi: 10.1016/j.bbrc.2008.04.176. Epub 2008 May 15. Biochem Biophys Res Commun. 2008. PMID: 18485895

5

Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function.

Hasegawa K, Wakino S, Yoshioka K, Tatematsu S, Hara Y, Minakuchi H, Sueyasu K, Washida N, Tokuyama H, Tzukerman M, Skorecki K, Hayashi K, Itoh H. Hasegawa K, et al. Among authors: tokuyama h. J Biol Chem. 2010 Apr 23;285(17):13045-56. doi: 10.1074/jbc.M109.067728. Epub 2010 Feb 5. J Biol Chem. 2010. PMID: 20139070 Free PMC article.

6

Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.

Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K, Itoh H. Hara Y, et al. Among authors: tokuyama h. Sci Signal. 2011 Jan 25;4(157):ra3. doi: 10.1126/scisignal.2001227. Sci Signal. 2011. PMID: 21266714

7

Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis.

Washida N, Wakino S, Tonozuka Y, Homma K, Tokuyama H, Hara Y, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Itoh H. Washida N, et al. Among authors: tokuyama h. Nephrol Dial Transplant. 2011 Sep;26(9):2770-9. doi: 10.1093/ndt/gfr012. Epub 2011 Mar 4. Nephrol Dial Transplant. 2011. PMID: 21378147

8

Ghrelin protects against renal damages induced by angiotensin-II via an antioxidative stress mechanism in mice.

Fujimura K, Wakino S, Minakuchi H, Hasegawa K, Hosoya K, Komatsu M, Kaneko Y, Shinozuka K, Washida N, Kanda T, Tokuyama H, Hayashi K, Itoh H. Fujimura K, et al. Among authors: tokuyama h. PLoS One. 2014 Apr 18;9(4):e94373. doi: 10.1371/journal.pone.0094373. eCollection 2014. PLoS One. 2014. PMID: 24747517 Free PMC article.

9

The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.

Minakuchi H, Wakino S, Hosoya K, Sueyasu K, Hasegawa K, Shinozuka K, Yoshifuji A, Futatsugi K, Komatsu M, Kanda T, Tokuyama H, Hayashi K, Itoh H. Minakuchi H, et al. Among authors: tokuyama h. Nephrol Dial Transplant. 2016 Mar;31(3):413-23. doi: 10.1093/ndt/gfv367. Epub 2015 Oct 28. Nephrol Dial Transplant. 2016. PMID: 26516203

10

Communication from Tubular Epithelial Cells to Podocytes through Sirt1 and Nicotinic Acid Metabolism.

Hasegawa K, Wakino S, Sakamaki Y, Muraoka H, Umino H, Minakuchi H, Yoshifuji A, Naitoh M, Shinozuka K, Futatsugi K, Urai H, Kanda T, Tokuyama H, Hayashi K, Itoh H. Hasegawa K, et al. Among authors: tokuyama h. Curr Hypertens Rev. 2016;12(2):95-104. doi: 10.2174/1573402112666160302102217. Curr Hypertens Rev. 2016. PMID: 26931474 Review.

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