Roth BL - Search Results

1

Photochemical activation of TRPA1 channels in neurons and animals.

Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. Kokel D, et al. Among authors: roth bl. Nat Chem Biol. 2013 Apr;9(4):257-63. doi: 10.1038/nchembio.1183. Epub 2013 Feb 10. Nat Chem Biol. 2013. PMID: 23396078 Free PMC article.

2

Regulation of 5-HT2 and 5-HT1C serotonin receptor levels. Methodology and mechanisms.

Roth BL, Hamblin M, Ciaranello RD. Roth BL, et al. Neuropsychopharmacology. 1990 Oct-Dec;3(5-6):427-33. Neuropsychopharmacology. 1990. PMID: 2078277 Review.

3

Why mice are neither miniature humans nor small rats: a cautionary tale involving 5-hydroxytryptamine-6 serotonin receptor species variants.

Setola V, Roth BL. Setola V, et al. Among authors: roth bl. Mol Pharmacol. 2003 Dec;64(6):1277-8. doi: 10.1124/mol.64.6.1277. Mol Pharmacol. 2003. PMID: 14645656 Review. No abstract available.

4

Molecular determinants for the interaction of the valvulopathic anorexigen norfenfluramine with the 5-HT2B receptor.

Setola V, Dukat M, Glennon RA, Roth BL. Setola V, et al. Among authors: roth bl. Mol Pharmacol. 2005 Jul;68(1):20-33. doi: 10.1124/mol.104.009266. Epub 2005 Apr 14. Mol Pharmacol. 2005. PMID: 15831837

5

Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.

Setola V, Roth BL. Setola V, et al. Among authors: roth bl. Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):377-87. doi: 10.1517/17425255.1.3.377. Expert Opin Drug Metab Toxicol. 2005. PMID: 16863450 Review.

6

Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.

Tang H, Wang XS, Huang XP, Roth BL, Butler KV, Kozikowski AP, Jung M, Tropsha A. Tang H, et al. Among authors: roth bl. J Chem Inf Model. 2009 Feb;49(2):461-76. doi: 10.1021/ci800366f. J Chem Inf Model. 2009. PMID: 19182860

7

N-tetrahydrothiochromenoisoxazole-1-carboxamides as selective antagonists of cloned human 5-HT2B.

Kwon YJ, Saubern S, Macdonald JM, Huang XP, Setola V, Roth BL. Kwon YJ, et al. Among authors: roth bl. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5488-90. doi: 10.1016/j.bmcl.2010.07.074. Epub 2010 Jul 21. Bioorg Med Chem Lett. 2010. PMID: 20692833

8

Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.

Hajjo R, Grulke CM, Golbraikh A, Setola V, Huang XP, Roth BL, Tropsha A. Hajjo R, et al. Among authors: roth bl. J Med Chem. 2010 Nov 11;53(21):7573-86. doi: 10.1021/jm100600y. J Med Chem. 2010. PMID: 20958049 Free PMC article.

9

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

Huang XP, Mangano T, Hufeisen S, Setola V, Roth BL. Huang XP, et al. Among authors: roth bl. Assay Drug Dev Technol. 2010 Dec;8(6):727-42. doi: 10.1089/adt.2010.0331. Assay Drug Dev Technol. 2010. PMID: 21158687 Free PMC article.

10

Serotonin receptors and heart valve disease--it was meant 2B.

Hutcheson JD, Setola V, Roth BL, Merryman WD. Hutcheson JD, et al. Among authors: roth bl. Pharmacol Ther. 2011 Nov;132(2):146-57. doi: 10.1016/j.pharmthera.2011.03.008. Epub 2011 Apr 2. Pharmacol Ther. 2011. PMID: 21440001 Free PMC article. Review.

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