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Page 1
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q. Zheng X, et al. Among authors: koivunen p. Genes Dev. 2014 Jul 1;28(13):1429-44. doi: 10.1101/gad.242131.114. Genes Dev. 2014. PMID: 24990963 Free PMC article.
A genetic mechanism for Tibetan high-altitude adaptation.
Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG Jr, Koivunen P, Prchal JT. Lorenzo FR, et al. Among authors: koivunen p. Nat Genet. 2014 Sep;46(9):951-6. doi: 10.1038/ng.3067. Epub 2014 Aug 17. Nat Genet. 2014. PMID: 25129147 Free PMC article.
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.
Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG Jr. Briggs KJ, et al. Among authors: koivunen p. Cell. 2016 Jun 30;166(1):126-39. doi: 10.1016/j.cell.2016.05.042. Cell. 2016. PMID: 27368101 Free PMC article.
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate.
Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG Jr. Chakraborty AA, et al. Among authors: koivunen p. Science. 2019 Mar 15;363(6432):1217-1222. doi: 10.1126/science.aaw1026. Epub 2019 Mar 14. Science. 2019. PMID: 30872525 Free PMC article.
2-Oxoglutarate-dependent dioxygenases in cancer.
Losman JA, Koivunen P, Kaelin WG Jr. Losman JA, et al. Among authors: koivunen p. Nat Rev Cancer. 2020 Dec;20(12):710-726. doi: 10.1038/s41568-020-00303-3. Epub 2020 Oct 21. Nat Rev Cancer. 2020. PMID: 33087883 Review.
(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.
Gunn K, Myllykoski M, Cao JZ, Ahmed M, Huang B, Rouaisnel B, Diplas BH, Levitt MM, Looper R, Doench JG, Ligon KL, Kornblum HI, McBrayer SK, Yan H, Duy C, Godley LA, Koivunen P, Losman JA. Gunn K, et al. Among authors: koivunen p. Cancer Discov. 2023 Jun 2;13(6):1478-1497. doi: 10.1158/2159-8290.CD-22-0825. Cancer Discov. 2023. PMID: 36847506 Free PMC article.
216 results