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Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.
Ohsawa F, Yamada S, Yakushiji N, Shinozaki R, Nakayama M, Kawata K, Hagaya M, Kobayashi T, Kohara K, Furusawa Y, Fujiwara C, Ohta Y, Makishima M, Naitou H, Tai A, Yoshikawa Y, Yasui H, Kakuta H. Ohsawa F, et al. Among authors: kobayashi t. J Med Chem. 2013 Mar 14;56(5):1865-77. doi: 10.1021/jm400033f. Epub 2013 Feb 20. J Med Chem. 2013. PMID: 23391145
RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects.
Kawata K, Morishita K, Nakayama M, Yamada S, Kobayashi T, Furusawa Y, Arimoto-Kobayashi S, Oohashi T, Makishima M, Naitou H, Ishitsubo E, Tokiwa H, Tai A, Kakuta H. Kawata K, et al. Among authors: kobayashi t. J Med Chem. 2015 Jan 22;58(2):912-26. doi: 10.1021/jm501863r. Epub 2014 Dec 17. J Med Chem. 2015. PMID: 25486327
Propensity score-matched real-world comparative treatment outcomes of Janus kinase inhibitors for ulcerative colitis in patients with and without prior exposure to anti-tumor necrosis factor α antibody.
Ikenouchi M, Fukui H, Yagi S, Nogami A, Kaku K, Sato T, Kawai M, Kamikozuru K, Yokoyama Y, Takagawa T, Tomita T, Kobayashi T, Shinzaki S. Ikenouchi M, et al. Among authors: kobayashi t. Intest Res. 2025 Feb 3. doi: 10.5217/ir.2024.00148. Online ahead of print. Intest Res. 2025. PMID: 39894450 Free article.
Outcomes of Patent Ductus Arteriosus Closureby Availability of Cardiac Surgeons for Infants Born Preterm.
Takeda T, Isayama T, Kobayashi T, Amari S, Nakao A, Toyoshima K, Masutani S; PLASE (Patent ductus arteriosus and Left Atrial Size Evaluation in preterm infants) study group investigators. Takeda T, et al. Among authors: kobayashi t. J Pediatr. 2025 Jan 29:114492. doi: 10.1016/j.jpeds.2025.114492. Online ahead of print. J Pediatr. 2025. PMID: 39889901
Fresh frozen plasma, fibrinogen concentrate, and antithrombin concentrate administration for obstetrical disseminated intravascular coagulation by the Japanese previous and new criteria.
Morikawa M, Matsunaga S, Makino S, Takeda Y, Hyodo H, Nii M, Serizawa M, Eto E, Takeda J, Adachi T, Kobayashi T, Itakura A. Morikawa M, et al. Among authors: kobayashi t. J Obstet Gynaecol Res. 2025 Feb;51(2):e16220. doi: 10.1111/jog.16220. J Obstet Gynaecol Res. 2025. PMID: 39887536
Cluster Analysis of HCC Prognosis Using Preoperative AFP and DCP Levels: A Multi-Institutional Study.
Saegusa Y, Imaoka Y, Ohira M, Kobayashi T, Honmyo N, Hamaoka M, Onoe T, Takei D, Oishi K, Abe T, Nakayama T, Akabane M, Sasaki K, Ohdan H; Hiroshima Surgical study group of Clinical Oncology (HiSCO). Saegusa Y, et al. Among authors: kobayashi t. J Gastrointest Surg. 2025 Jan 28:101980. doi: 10.1016/j.gassur.2025.101980. Online ahead of print. J Gastrointest Surg. 2025. PMID: 39884550
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