Kakuta H - Search Results

1

Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.

Ohsawa F, Yamada S, Yakushiji N, Shinozaki R, Nakayama M, Kawata K, Hagaya M, Kobayashi T, Kohara K, Furusawa Y, Fujiwara C, Ohta Y, Makishima M, Naitou H, Tai A, Yoshikawa Y, Yasui H, Kakuta H. Ohsawa F, et al. Among authors: kakuta h. J Med Chem. 2013 Mar 14;56(5):1865-77. doi: 10.1021/jm400033f. Epub 2013 Feb 20. J Med Chem. 2013. PMID: 23391145

2

Antimalarial effect of bis-pyridinium salts, N,N'-hexamethylenebis(4-carbamoyl-1-alkylpyridinium bromide).

Fujimoto K, Morisaki D, Yoshida M, Namba T, Hye-Sook K, Wataya Y, Kourai H, Kakuta H, Sasaki K. Fujimoto K, et al. Among authors: kakuta h. Bioorg Med Chem Lett. 2006 May 15;16(10):2758-60. doi: 10.1016/j.bmcl.2006.02.030. Epub 2006 Mar 9. Bioorg Med Chem Lett. 2006. PMID: 16524728

3

Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.

Zheng X, Oda H, Takamatsu K, Sugimoto Y, Tai A, Akaho E, Ali HI, Oshiki T, Kakuta H, Sasaki K. Zheng X, et al. Among authors: kakuta h. Bioorg Med Chem. 2007 Jan 15;15(2):1014-21. doi: 10.1016/j.bmc.2006.10.029. Epub 2006 Oct 18. Bioorg Med Chem. 2007. PMID: 17079150

4

Antimalarial cation-dimers synthesized in two steps from an inexpensive starting material, isonicotinic acid.

Motoshima K, Hiwasa Y, Yoshikawa M, Fujimoto K, Tai A, Kakuta H, Sasaki K. Motoshima K, et al. Among authors: kakuta h. ChemMedChem. 2007 Oct;2(10):1527-32. doi: 10.1002/cmdc.200700107. ChemMedChem. 2007. PMID: 17607684

5

Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRalpha-preferential agonist possessing a sulfonamide moiety.

Takamatsu K, Takano A, Yakushiji N, Morishita K, Matsuura N, Makishima M, Ali HI, Akaho E, Tai A, Sasaki K, Kakuta H. Takamatsu K, et al. Among authors: kakuta h. ChemMedChem. 2008 Mar;3(3):454-60. doi: 10.1002/cmdc.200700265. ChemMedChem. 2008. PMID: 18157857

6

The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRalpha/beta-dual agonist).

Takamatsu K, Takano A, Yakushiji N, Morohashi K, Morishita K, Matsuura N, Makishima M, Tai A, Sasaki K, Kakuta H. Takamatsu K, et al. Among authors: kakuta h. ChemMedChem. 2008 May;3(5):780-7. doi: 10.1002/cmdc.200700313. ChemMedChem. 2008. PMID: 18297677

7

Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor.

Kakuta H, Zheng X, Oda H, Harada S, Sugimoto Y, Sasaki K, Tai A. Kakuta H, et al. J Med Chem. 2008 Apr 24;51(8):2400-11. doi: 10.1021/jm701191z. Epub 2008 Mar 26. J Med Chem. 2008. PMID: 18363350

8

Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation.

Zheng X, Oda H, Harada S, Sugimoto Y, Tai A, Sasaki K, Kakuta H. Zheng X, et al. Among authors: kakuta h. J Pharm Sci. 2008 Dec;97(12):5446-52. doi: 10.1002/jps.21388. J Pharm Sci. 2008. PMID: 18452178

9

Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus.

Namba K, Zheng X, Motoshima K, Kobayashi H, Tai A, Takahashi E, Sasaki K, Okamoto K, Kakuta H. Namba K, et al. Among authors: kakuta h. Bioorg Med Chem. 2008 Jun 1;16(11):6131-44. doi: 10.1016/j.bmc.2008.04.040. Epub 2008 Apr 24. Bioorg Med Chem. 2008. PMID: 18468909

10

Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum.

Yoshikawa M, Motoshima K, Fujimoto K, Tai A, Kakuta H, Sasaki K. Yoshikawa M, et al. Among authors: kakuta h. Bioorg Med Chem. 2008 Jun 1;16(11):6027-33. doi: 10.1016/j.bmc.2008.04.051. Epub 2008 Apr 25. Bioorg Med Chem. 2008. PMID: 18479926

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