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A phase II study of temsirolimus and erlotinib in patients with recurrent and/or metastatic, platinum-refractory head and neck squamous cell carcinoma.
Bauman JE, Arias-Pulido H, Lee SJ, Fekrazad MH, Ozawa H, Fertig E, Howard J, Bishop J, Wang H, Olson GT, Spafford MJ, Jones DV, Chung CH. Bauman JE, et al. Among authors: ozawa h. Oral Oncol. 2013 May;49(5):461-7. doi: 10.1016/j.oraloncology.2012.12.016. Epub 2013 Feb 4. Oral Oncol. 2013. PMID: 23384718 Free PMC article. Clinical Trial.
Decreased SMAD4 expression is associated with induction of epithelial-to-mesenchymal transition and cetuximab resistance in head and neck squamous cell carcinoma.
Cheng H, Fertig EJ, Ozawa H, Hatakeyama H, Howard JD, Perez J, Considine M, Thakar M, Ranaweera R, Krigsfeld G, Chung CH. Cheng H, et al. Among authors: ozawa h. Cancer Biol Ther. 2015;16(8):1252-8. doi: 10.1080/15384047.2015.1056418. Epub 2015 Jun 5. Cancer Biol Ther. 2015. PMID: 26046389 Free PMC article.
Cetuximab activity in dysplastic lesions of the upper aerodigestive tract.
Khan Z, Epstein JB, Marur S, Gillespie MB, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris R, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung C, Califano JA. Khan Z, et al. Among authors: ozawa h. Oral Oncol. 2016 Feb;53:60-6. doi: 10.1016/j.oraloncology.2015.11.016. Epub 2015 Dec 10. Oral Oncol. 2016. PMID: 26686755 Free PMC article. Clinical Trial.
CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network.
Fertig EJ, Ozawa H, Thakar M, Howard JD, Kagohara LT, Krigsfeld G, Ranaweera RS, Hughes RM, Perez J, Jones S, Favorov AV, Carey J, Stein-O'Brien G, Gaykalova DA, Ochs MF, Chung CH. Fertig EJ, et al. Among authors: ozawa h. Oncotarget. 2016 Nov 8;7(45):73845-73864. doi: 10.18632/oncotarget.12075. Oncotarget. 2016. PMID: 27650546 Free PMC article.
SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells.
Ozawa H, Ranaweera RS, Izumchenko E, Makarev E, Zhavoronkov A, Fertig EJ, Howard JD, Markovic A, Bedi A, Ravi R, Perez J, Le QT, Kong CS, Jordan RC, Wang H, Kang H, Quon H, Sidransky D, Chung CH. Ozawa H, et al. Clin Cancer Res. 2017 Sep 1;23(17):5162-5175. doi: 10.1158/1078-0432.CCR-16-1686. Epub 2017 May 18. Clin Cancer Res. 2017. PMID: 28522603 Free PMC article.
NF-κB and stat3 transcription factor signatures differentiate HPV-positive and HPV-negative head and neck squamous cell carcinoma.
Gaykalova DA, Manola JB, Ozawa H, Zizkova V, Morton K, Bishop JA, Sharma R, Zhang C, Michailidi C, Considine M, Tan M, Fertig EJ, Hennessey PT, Ahn J, Koch WM, Westra WH, Khan Z, Chung CH, Ochs MF, Califano JA. Gaykalova DA, et al. Among authors: ozawa h. Int J Cancer. 2015 Oct 15;137(8):1879-89. doi: 10.1002/ijc.29558. Epub 2015 Jun 23. Int J Cancer. 2015. PMID: 25857630 Free PMC article.
Corrigendum to "Cetuximab activity in dysplastic lesions of the upper aerodigestive tract" [Oral Oncol. 53 (2016) 60-66].
Khan Z, Epstein JB, Marur S, Boyd Gillespie M, Feldman L, Tsai HL, Zhang Z, Wang H, Sciubba J, Ferris RL, Grandis JR, Gibson M, Koch W, Tufano R, Westra W, Tsottles N, Ozawa H, Chung CH, Califano JA. Khan Z, et al. Among authors: ozawa h. Oral Oncol. 2016 Jun;57:e8. doi: 10.1016/j.oraloncology.2016.03.018. Epub 2016 Apr 13. Oral Oncol. 2016. PMID: 27085635 Free PMC article. No abstract available.
Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance.
Stein-O'Brien G, Kagohara LT, Li S, Thakar M, Ranaweera R, Ozawa H, Cheng H, Considine M, Schmitz S, Favorov AV, Danilova LV, Califano JA, Izumchenko E, Gaykalova DA, Chung CH, Fertig EJ. Stein-O'Brien G, et al. Among authors: ozawa h. Genome Med. 2018 May 23;10(1):37. doi: 10.1186/s13073-018-0545-2. Genome Med. 2018. PMID: 29792227 Free PMC article.
1,619 results