Marais R - Search Results

1

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.

Niculescu-Duvaz D, Niculescu-Duvaz I, Suijkerbuijk BM, Ménard D, Zambon A, Davies L, Pons JF, Whittaker S, Marais R, Springer CJ. Niculescu-Duvaz D, et al. Among authors: marais r. Bioorg Med Chem. 2013 Mar 1;21(5):1284-304. doi: 10.1016/j.bmc.2012.12.035. Epub 2013 Jan 3. Bioorg Med Chem. 2013. PMID: 23376011

2

Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination.

Marais R, Spooner RA, Light Y, Martin J, Springer CJ. Marais R, et al. Cancer Res. 1996 Oct 15;56(20):4735-42. Cancer Res. 1996. PMID: 8840992

3

A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy.

Marais R, Spooner RA, Stribbling SM, Light Y, Martin J, Springer CJ. Marais R, et al. Nat Biotechnol. 1997 Dec;15(13):1373-7. doi: 10.1038/nbt1297-1373. Nat Biotechnol. 1997. PMID: 9415889

4

Gene-directed enzyme prodrug therapy.

Niculescu-Duvaz I, Spooner R, Marais R, Springer CJ. Niculescu-Duvaz I, et al. Among authors: marais r. Bioconjug Chem. 1998 Jan-Feb;9(1):4-22. doi: 10.1021/bc970116t. Bioconjug Chem. 1998. PMID: 9460542 Review. No abstract available.

5

Self-immolative nitrogen mustard prodrugs for suicide gene therapy.

Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Spooner R, Davies L, Marais R, Springer CJ. Niculescu-Duvaz D, et al. Among authors: marais r. J Med Chem. 1998 Dec 17;41(26):5297-309. doi: 10.1021/jm980425k. J Med Chem. 1998. PMID: 9857097

6

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.

Mason CS, Springer CJ, Cooper RG, Superti-Furga G, Marshall CJ, Marais R. Mason CS, et al. Among authors: marais r. EMBO J. 1999 Apr 15;18(8):2137-48. doi: 10.1093/emboj/18.8.2137. EMBO J. 1999. PMID: 10205168 Free PMC article.

7

Self-immolative anthracycline prodrugs for suicide gene therapy.

Niculescu-Duvaz I, Niculescu-Duvaz D, Friedlos F, Spooner R, Martin J, Marais R, Springer CJ. Niculescu-Duvaz I, et al. Among authors: marais r. J Med Chem. 1999 Jul 1;42(13):2485-9. doi: 10.1021/jm980696v. J Med Chem. 1999. PMID: 10395490

8

Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect.

Stribbling SM, Friedlos F, Martin J, Davies L, Spooner RA, Marais R, Springer CJ. Stribbling SM, et al. Among authors: marais r. Hum Gene Ther. 2000 Jan 20;11(2):285-92. doi: 10.1089/10430340050016021. Hum Gene Ther. 2000. PMID: 10680842

9

In suicide gene therapy, the site of subcellular localization of the activating enzyme is more important than the rate at which it activates prodrug.

Spooner RA, Martin J, Friedlos F, Marais R, Springer CJ. Spooner RA, et al. Among authors: marais r. Cancer Gene Ther. 2000 Oct;7(10):1348-56. doi: 10.1038/sj.cgt.7700243. Cancer Gene Ther. 2000. PMID: 11059693

10

Appropriate subcellular localisation of prodrug-activating enzymes has important consequences for suicide gene therapy.

Spooner RA, Maycroft KA, Paterson H, Friedlos F, Springer CJ, Marais R. Spooner RA, et al. Among authors: marais r. Int J Cancer. 2001 Jul 1;93(1):123-30. doi: 10.1002/ijc.1288. Int J Cancer. 2001. PMID: 11391631

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