Wright DL - Search Results

1

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.

Paulsen JL, Viswanathan K, Wright DL, Anderson AC. Paulsen JL, et al. Among authors: wright dl. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1279-84. doi: 10.1016/j.bmcl.2013.01.008. Epub 2013 Jan 11. Bioorg Med Chem Lett. 2013. PMID: 23375226 Free PMC article.

2

Highly efficient ligands for dihydrofolate reductase from Cryptosporidium hominis and Toxoplasma gondii inspired by structural analysis.

Pelphrey PM, Popov VM, Joska TM, Beierlein JM, Bolstad ES, Fillingham YA, Wright DL, Anderson AC. Pelphrey PM, et al. Among authors: wright dl. J Med Chem. 2007 Mar 8;50(5):940-50. doi: 10.1021/jm061027h. Epub 2007 Feb 2. J Med Chem. 2007. PMID: 17269758

3

Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.

Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Liu J, et al. Among authors: wright dl. Chem Biol. 2008 Sep 22;15(9):990-6. doi: 10.1016/j.chembiol.2008.07.013. Chem Biol. 2008. PMID: 18804036 Free PMC article.

4

Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.

Bolstad DB, Bolstad ES, Frey KM, Wright DL, Anderson AC. Bolstad DB, et al. Among authors: wright dl. J Med Chem. 2008 Nov 13;51(21):6839-52. doi: 10.1021/jm8009124. Epub 2008 Oct 4. J Med Chem. 2008. PMID: 18834108 Free PMC article.

5

Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase.

Beierlein JM, Frey KM, Bolstad DB, Pelphrey PM, Joska TM, Smith AE, Priestley ND, Wright DL, Anderson AC. Beierlein JM, et al. Among authors: wright dl. J Med Chem. 2008 Dec 11;51(23):7532-40. doi: 10.1021/jm800776a. J Med Chem. 2008. PMID: 19007108 Free PMC article.

6

Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors.

Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Liu J, et al. Among authors: wright dl. Chem Biol Drug Des. 2009 Jan;73(1):62-74. doi: 10.1111/j.1747-0285.2008.00745.x. Chem Biol Drug Des. 2009. PMID: 19152636 Free PMC article.

7

Towards new antifolates targeting eukaryotic opportunistic infections.

Liu J, Bolstad DB, Bolstad ES, Wright DL, Anderson AC. Liu J, et al. Among authors: wright dl. Eukaryot Cell. 2009 Apr;8(4):483-6. doi: 10.1128/EC.00298-08. Epub 2009 Jan 23. Eukaryot Cell. 2009. PMID: 19168759 Free PMC article.

8

Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.

Frey KM, Liu J, Lombardo MN, Bolstad DB, Wright DL, Anderson AC. Frey KM, et al. Among authors: wright dl. J Mol Biol. 2009 Apr 17;387(5):1298-308. doi: 10.1016/j.jmb.2009.02.045. Epub 2009 Feb 26. J Mol Biol. 2009. PMID: 19249312 Free PMC article.

9

In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.

Paulsen JL, Liu J, Bolstad DB, Smith AE, Priestley ND, Wright DL, Anderson AC. Paulsen JL, et al. Among authors: wright dl. Bioorg Med Chem. 2009 Jul 15;17(14):4866-72. doi: 10.1016/j.bmc.2009.06.021. Epub 2009 Jun 17. Bioorg Med Chem. 2009. PMID: 19560363 Free PMC article.

10

Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase.

Frey KM, Lombardo MN, Wright DL, Anderson AC. Frey KM, et al. Among authors: wright dl. J Struct Biol. 2010 Apr;170(1):93-7. doi: 10.1016/j.jsb.2009.12.011. Epub 2009 Dec 21. J Struct Biol. 2010. PMID: 20026215 Free PMC article.

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