Xiao SH - Search Results

1

Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.

Li K, McGee LR, Fisher B, Sudom A, Liu J, Rubenstein SM, Anwer MK, Cushing TD, Shin Y, Ayres M, Lee F, Eksterowicz J, Faulder P, Waszkowycz B, Plotnikova O, Farrelly E, Xiao SH, Chen G, Wang Z. Li K, et al. Among authors: xiao sh. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1238-44. doi: 10.1016/j.bmcl.2013.01.012. Epub 2013 Jan 11. Bioorg Med Chem Lett. 2013. PMID: 23374866

2

An ultrasensitive high-throughput electrochemiluminescence immunoassay for the Cdc42-associated protein tyrosine kinase ACK1.

Xiao SH, Farrelly E, Anzola J, Crawford D, Jiao X, Liu J, Ayres M, Li S, Huang L, Sharma R, Kayser F, Wesche H, Young SW. Xiao SH, et al. Anal Biochem. 2007 Aug 15;367(2):179-89. doi: 10.1016/j.ab.2007.05.007. Epub 2007 May 10. Anal Biochem. 2007. PMID: 17592719

3

Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.

Kopecky DJ, Hao X, Chen Y, Fu J, Jiao X, Jaen JC, Cardozo MG, Liu J, Wang Z, Walker NP, Wesche H, Li S, Farrelly E, Xiao SH, Kayser F. Kopecky DJ, et al. Among authors: xiao sh. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6352-6. doi: 10.1016/j.bmcl.2008.10.092. Epub 2008 Nov 1. Bioorg Med Chem Lett. 2008. PMID: 18993068

4

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.

Gustin DJ, Ma Z, Min X, Li Y, Hedberg C, Guimaraes C, Porter AC, Lindstrom M, Lester-Zeiner D, Xu G, Carlson TJ, Xiao S, Meleza C, Connors R, Wang Z, Kayser F. Gustin DJ, et al. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2492-6. doi: 10.1016/j.bmcl.2011.02.052. Epub 2011 Feb 17. Bioorg Med Chem Lett. 2011. PMID: 21392988

5

Novel pyrrolidine melanin-concentrating hormone receptor 1 antagonists with reduced hERG inhibition.

Fox BM, Natero R, Richard K, Connors R, Roveto PM, Beckmann H, Haller K, Golde J, Xiao SH, Kayser F. Fox BM, et al. Among authors: xiao sh. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2460-7. doi: 10.1016/j.bmcl.2011.02.046. Epub 2011 Mar 15. Bioorg Med Chem Lett. 2011. PMID: 21414780

6

Development of a time-resolved fluorescence resonance energy transfer assay for cyclin-dependent kinase 4 and identification of its ATP-noncompetitive inhibitors.

Lo MC, Ngo R, Dai K, Li C, Liang L, Lee J, Emkey R, Eksterowicz J, Ventura M, Young SW, Xiao SH. Lo MC, et al. Among authors: xiao sh. Anal Biochem. 2012 Feb 15;421(2):368-77. doi: 10.1016/j.ab.2011.10.014. Epub 2011 Oct 12. Anal Biochem. 2012. PMID: 22056947

7

Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.

Jiao X, Kopecky DJ, Liu J, Liu J, Jaen JC, Cardozo MG, Sharma R, Walker N, Wesche H, Li S, Farrelly E, Xiao SH, Wang Z, Kayser F. Jiao X, et al. Among authors: xiao sh. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6212-7. doi: 10.1016/j.bmcl.2012.08.020. Epub 2012 Aug 10. Bioorg Med Chem Lett. 2012. PMID: 22929232

8

Rational design and binding mode duality of MDM2-p53 inhibitors.

Gonzalez-Lopez de Turiso F, Sun D, Rew Y, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Correll TL, Huang X, Julian LD, Kayser F, Lo MC, Long AM, McMinn D, Oliner JD, Osgood T, Powers JP, Saiki AY, Schneider S, Shaffer P, Xiao SH, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Medina JC, Olson SH. Gonzalez-Lopez de Turiso F, et al. Among authors: xiao sh. J Med Chem. 2013 May 23;56(10):4053-70. doi: 10.1021/jm400293z. Epub 2013 May 6. J Med Chem. 2013. PMID: 23597064

9

Molecular basis of sphingosine kinase 1 substrate recognition and catalysis.

Wang Z, Min X, Xiao SH, Johnstone S, Romanow W, Meininger D, Xu H, Liu J, Dai J, An S, Thibault S, Walker N. Wang Z, et al. Among authors: xiao sh. Structure. 2013 May 7;21(5):798-809. doi: 10.1016/j.str.2013.02.025. Epub 2013 Apr 18. Structure. 2013. PMID: 23602659 Free article.

10

Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.

Rowley AM, Yao G, Andrews L, Bedermann A, Biddulph R, Bingham R, Brady JJ, Buxton R, Cecconie T, Cooper R, Csakai A, Gao EN, Grenier-Davies MC, Lawler M, Lian Y, Macina J, Macphee C, Marcaurelle L, Martin J, McCormick P, Pindoria R, Rauch M, Rocque W, Shen Y, Shewchuk LM, Squire M, Stebbeds W, Tear W, Wang X, Ward P, Xiao S. Rowley AM, et al. J Med Chem. 2024 Feb 8;67(3):2049-2065. doi: 10.1021/acs.jmedchem.3c01562. Epub 2024 Jan 29. J Med Chem. 2024. PMID: 38284310

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