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Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, Keck GE. Kedei N, et al. Among authors: selezneva j. ACS Chem Biol. 2013 Apr 19;8(4):767-77. doi: 10.1021/cb300671s. Epub 2013 Feb 1. ACS Chem Biol. 2013. PMID: 23369356 Free PMC article.
Charge density influences C1 domain ligand affinity and membrane interactions.
Kelsey JS, Geczy T, Lewin NE, Kedei N, Hill CS, Selezneva JS, Valle CJ, Woo W, Gorshkova I, Blumberg PM. Kelsey JS, et al. Among authors: selezneva js. Chembiochem. 2014 May 26;15(8):1131-1144. doi: 10.1002/cbic.201400041. Epub 2014 Apr 28. Chembiochem. 2014. PMID: 24777910 Free PMC article.