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Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, Keck GE. Kedei N, et al. Among authors: keck ge. ACS Chem Biol. 2013 Apr 19;8(4):767-77. doi: 10.1021/cb300671s. Epub 2013 Feb 1. ACS Chem Biol. 2013. PMID: 23369356 Free PMC article.
Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action.
Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM. Kedei N, et al. Among authors: keck ge. Biochem Pharmacol. 2013 Feb 1;85(3):313-24. doi: 10.1016/j.bcp.2012.10.028. Epub 2012 Nov 9. Biochem Pharmacol. 2013. PMID: 23146662 Free PMC article.
The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.
Kedei N, Telek A, Czap A, Lubart ES, Czifra G, Yang D, Chen J, Morrison T, Goldsmith PK, Lim L, Mannan P, Garfield SH, Kraft MB, Li W, Keck GE, Blumberg PM. Kedei N, et al. Among authors: keck ge. Biochem Pharmacol. 2011 Jun 1;81(11):1296-308. doi: 10.1016/j.bcp.2011.03.018. Epub 2011 Mar 30. Biochem Pharmacol. 2011. PMID: 21458422 Free PMC article.
Synthesis and Biological Evaluation of Fluorescent Bryostatin Analogues.
Cummins TJ, Kedei N, Czikora A, Lewin NE, Kirk S, Petersen ME, McGowan KM, Chen JQ, Luo X, Johnson RC, Ravichandran S, Blumberg PM, Keck GE. Cummins TJ, et al. Among authors: keck ge. Chembiochem. 2018 Apr 16;19(8):877-889. doi: 10.1002/cbic.201700655. Epub 2018 Mar 25. Chembiochem. 2018. PMID: 29424951 Free PMC article.
41 results